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Gene therapy to treat cardiovascular disease.

作者信息

Wolfram Julie A, Donahue J Kevin

机构信息

Department of Medicine, MetroHealth Campus of Case Western Reserve University, Cleveland, OH.

出版信息

J Am Heart Assoc. 2013 Aug 20;2(4):e000119. doi: 10.1161/JAHA.113.000119.

DOI:10.1161/JAHA.113.000119
PMID:23963752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3828796/
Abstract
摘要

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2
Site-specific gene therapy for cardiovascular disease.心血管疾病的位点特异性基因治疗。
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Method of gene delivery in large animal models of cardiovascular diseases.心血管疾病大型动物模型中的基因递送方法。
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Gene therapy in cardiovascular surgery.
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Ten steps to gene therapy for cardiovascular diseases.
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The emerging role of gene therapy in the treatment of cardiovascular diseases.基因治疗在心血管疾病治疗中的新兴作用。
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Gene therapy in the cardiovascular system: an update.心血管系统中的基因治疗:最新进展
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本文引用的文献

1
Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles.超声与微泡介导的心血管疾病基因治疗
Cardiovasc Ultrasound. 2013 Apr 17;11:11. doi: 10.1186/1476-7120-11-11.
2
Janus-like role of fibroblast growth factor 2 in arteriosclerotic coronary artery disease: atherogenesis and angiogenesis.成纤维细胞生长因子 2 在动脉粥样硬化性冠状动脉疾病中的双面作用:动脉粥样硬化形成和血管生成。
Atherosclerosis. 2013 Jul;229(1):10-7. doi: 10.1016/j.atherosclerosis.2013.03.013. Epub 2013 Mar 26.
3
An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure.一项评价非病毒基质细胞衍生因子-1 质粒给药治疗有症状缺血性心力衰竭安全性的开放性标签剂量递增研究。
Circ Res. 2013 Mar 1;112(5):816-25. doi: 10.1161/CIRCRESAHA.111.300440. Epub 2013 Feb 21.
4
Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance.非典型 EF 手基序策略性地延迟 Ca2+缓冲以增强心脏功能。
Nat Med. 2013 Mar;19(3):305-12. doi: 10.1038/nm.3079. Epub 2013 Feb 10.
5
HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.将 HCN2/SkM1 基因转染至犬左侧束支可在生理心率下诱导稳定、自主响应的生物起搏。
J Am Coll Cardiol. 2013 Mar 19;61(11):1192-201. doi: 10.1016/j.jacc.2012.12.031. Epub 2013 Feb 6.
6
Flushing out antibodies to make AAV gene therapy available to more patients.清除抗体以使更多患者能够接受腺相关病毒基因疗法。
Mol Ther. 2013 Feb;21(2):269-71. doi: 10.1038/mt.2013.5.
7
Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.执行摘要:《2013年心脏病和中风统计数据更新:美国心脏协会报告》
Circulation. 2013 Jan 1;127(1):143-52. doi: 10.1161/CIR.0b013e318282ab8f.
8
Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.最小化中和抗体对腺相关病毒 8 载体在肝脏中高效基因表达的抑制作用。
Mol Ther. 2013 Feb;21(2):318-23. doi: 10.1038/mt.2012.258. Epub 2012 Dec 18.
9
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.《2013年心脏病和中风统计数据更新:美国心脏协会报告》
Circulation. 2013 Jan 1;127(1):e6-e245. doi: 10.1161/CIR.0b013e31828124ad. Epub 2012 Dec 12.
10
Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.缝隙连接蛋白 43 基因转染减少心肌梗死后室性心动过速易感性。
J Am Coll Cardiol. 2012 Sep 18;60(12):1103-10. doi: 10.1016/j.jacc.2012.04.042. Epub 2012 Aug 8.