Ramírez A, Gil M, Martínez Ríos M A, Cárdenas M, Pliego J, Zamora C, Mata L A
Arch Inst Cardiol Mex. 1982 Jan-Feb;52(1):63-8.
Four hundred patients with atrial septal defect treated surgically were reviewed. Thirty five (8.7%) developed arrhytmias post-surgery which persisted for over a year. Sinus bradycardia was found in 10 patients, nodal rhythm in 21, and atrial fibrilation and flutter in 4 patients. Thirty five per cent of the patients with late arrhythmias developed related symptomatology. In 14 patients the function of the sinus node was studied with electrical stimulation of the atrium and with His registry. The interatrial conduction time, AV node and His Purkinje were analized employing various stimulation frequencies. All the cases studied had normal intra-atrial conduction; the response of the atrio-ventricular node to increasing frequencies was normal, an the intraventricular conduction remained constant. In 8 patients (52%), alterations of the sinus node were found; these consisted of prolonged post-stimulation pauses, Wenckebach's type sinoatrial block and suppression of sinus automatism employing vagal procedures or through electrical stimulation. A patient with severe bradycardia detected by dynamic electrocardiography had to be treated with a permanent pacemaker. We confirm that these arrhytmias are not produced by lesions of the internodal tracts, and that an alteration of the sinus node is frequent without a concomitant lesion of the intraventricular pathway. The lesion to the nutrient artery could be due to trauma and/or surgically induced. The response to anticholinergic drugs was good. Prolonged observation of these patients could increase the morbility of these arrythmias and raise doubts of the surgical indications in cases with moderate hemodynamic repercussion.
对400例接受手术治疗的房间隔缺损患者进行了回顾性研究。35例(8.7%)术后出现心律失常,且持续超过一年。其中10例出现窦性心动过缓,21例出现结性心律,4例出现心房颤动和扑动。35%的晚期心律失常患者出现相关症状。对14例患者进行了心房电刺激和希氏束记录,以研究窦房结功能。采用不同的刺激频率分析了房间传导时间、房室结和希氏-浦肯野系统。所有研究病例的房内传导均正常;房室结对频率增加的反应正常,室内传导保持恒定。8例患者(52%)发现窦房结改变;这些改变包括刺激后停顿延长、文氏型窦房阻滞以及通过迷走神经操作或电刺激抑制窦房结自律性。一名通过动态心电图检测到严重心动过缓的患者必须接受永久性起搏器治疗。我们证实这些心律失常不是由结间束病变引起的,并且窦房结改变很常见,而室内传导通路没有伴随病变。营养动脉损伤可能是由于创伤和/或手术引起的。对抗胆碱能药物反应良好。对这些患者进行长期观察可能会增加这些心律失常的发病率,并对中度血流动力学影响病例的手术指征产生怀疑。