钯催化的脂肪族酰胺中 C(sp(3))-H 键的不对称芳基化反应：使用手性磷酸酰胺/酸控制对映选择性。
Palladium-Catalyzed Asymmetric Arylation of C(sp(3))-H Bonds of Aliphatic Amides: Controlling Enantioselectivity Using Chiral Phosphoric Amides/Acids.
机构信息
†State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
‡School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Org Lett. 2015 May 15;17(10):2458-61. doi: 10.1021/acs.orglett.5b00968. Epub 2015 May 4.
PMID:25937267
Abstract
Enantioselective arylation of secondary β-C(sp(3))-H bonds of 8-aminoquinoline amides was realized with a palladium catalyst. Chiral phosphoric amides and acids were used for the first time to control the stereoselectivity at the C-H bond cleavage step in the C-H activation reactions.
摘要
手性膦酰胺和酸被首次用于控制钯催化剂作用下的 8-氨基喹啉酰胺的仲β-C(sp(3))-H 键的不对称芳基化反应中 C-H 键断裂步骤的立体选择性。
Zotero 插件