Palomero-Gallagher Nicola, Eickhoff Simon B, Hoffstaedter Felix, Schleicher Axel, Mohlberg Hartmut, Vogt Brent A, Amunts Katrin, Zilles Karl
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany.
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, D-40225 Düsseldorf, Germany.
Neuroimage. 2015 Jul 15;115:177-90. doi: 10.1016/j.neuroimage.2015.04.053. Epub 2015 May 1.
Human subgenual anterior cingulate cortex (sACC) is involved in affective experiences and fear processing. Functional neuroimaging studies view it as a homogeneous cortical entity. However, sACC comprises several distinct cyto- and receptorarchitectonical areas: 25, s24, s32, and the ventral portion of area 33. Thus, we hypothesized that the areas may also be connectionally and functionally distinct. We performed structural post mortem and functional in vivo analyses. We computed probabilistic maps of each area based on cytoarchitectonical analysis of ten post mortem brains. Maps, publicly available via the JuBrain atlas and the Anatomy Toolbox, were used to define seed regions of task-dependent functional connectivity profiles and quantitative functional decoding. sACC areas presented distinct co-activation patterns within widespread networks encompassing cortical and subcortical regions. They shared common functional domains related to emotion, perception and cognition. A more specific analysis of these domains revealed an association of s24 with sadness, and of s32 with fear processing. Both areas were activated during taste evaluation, and co-activated with the amygdala, a key node of the affective network. s32 co-activated with areas of the executive control network, and was associated with tasks probing cognition in which stimuli did not have an emotional component. Area 33 was activated by painful stimuli, and co-activated with areas of the sensorimotor network. These results support the concept of a connectional and functional specificity of the cyto- and receptorarchitectonically defined areas within the sACC, which can no longer be seen as a structurally and functionally homogeneous brain region.
人类膝下前扣带回皮质（sACC）参与情感体验和恐惧处理。功能神经影像学研究将其视为一个同质的皮质实体。然而，sACC由几个不同的细胞和受体构筑区域组成：25区、24区、32区和33区的腹侧部分。因此，我们推测这些区域在连接和功能上也可能是不同的。我们进行了死后结构分析和活体功能分析。我们基于对10个死后大脑的细胞构筑分析计算了每个区域的概率图谱。通过JuBrain图谱和解剖工具箱可公开获取的图谱被用于定义任务依赖性功能连接图谱和定量功能解码的种子区域。sACC区域在包括皮质和皮质下区域的广泛网络中呈现出不同的共激活模式。它们共享与情感、感知和认知相关的共同功能域。对这些域的更具体分析揭示了24区与悲伤相关，32区与恐惧处理相关。在味觉评估期间，这两个区域均被激活，并与情感网络的关键节点杏仁核共同激活。32区与执行控制网络的区域共同激活，并与探测无情感成分刺激的认知任务相关。33区被疼痛刺激激活，并与感觉运动网络的区域共同激活。这些结果支持了sACC内细胞和受体构筑定义区域在连接和功能上具有特异性的概念，该区域不再能被视为一个结构和功能上同质的脑区。
