Sun Jian, Zheng Jinyu, Tang Linjun, Healy Jasmine, Sinnett Daniel, Dai Yue-e
Department of Anesthesiology, Huai'an Matenal and Child Health Hospital, Huai'an, Jiangsu, China.
Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
PLoS One. 2015 May 4;10(5):e0125657. doi: 10.1371/journal.pone.0125657. eCollection 2015.
The CCAAT/enhancer binding proteins (CEBPs) have been involved in the etiology of acute leukemia (AL) and investigated in numerous genetic association studies, however, the results were inconclusive. The current meta-analysis was conducted to clarify the effect of CEBPE rs2239633 variant on childhood AL risk. Electronic literature search was performed on August 15, 2014, from databases of Medline, PubMed, Embase, and Web of Science. A total of 22 case-control studies were eligible for the pooled analysis. The results demonstrated that rs2239633 A allele was significantly associated with a decreased risk of childhood AL (A vs G: OR=0.87, 95%CI = 0.80, 0.94, p<0.001), especially in B-cell ALL subgroup (A vs G: OR = 0.79, 95%CI = 0.74, 0.83, p<0.001), but not among T-cell ALL or AML subgroups. In the stratified analysis by ethnicity, the association was observed in Europeans (A vs G: OR = 0.80, 95%CI = 0.76, 0.84, p<0.001) but not in Asian and mixed populations. Moreover, the results of sensitivity and cumulative meta-analysis indicated the robustness of our results. Also, Begg's and Egger's tests did not indicate any evidence of obvious asymmetry. In summary, our study provided evidence that CEBPE rs2239633 variant is associated with decreased risk of childhood B-cell ALL in Europeans.
CCAAT/增强子结合蛋白（CEBPs）已被发现与急性白血病（AL）的病因有关，并且在众多基因关联研究中得到了调查，然而，结果尚无定论。当前的荟萃分析旨在阐明CEBPE rs2239633变体对儿童AL风险的影响。于2014年8月15日对Medline、PubMed、Embase和Web of Science数据库进行了电子文献检索。共有22项病例对照研究符合纳入荟萃分析的条件。结果表明，rs2239633 A等位基因与儿童AL风险降低显著相关（A与G相比：OR=0.87，95%CI = 0.80，0.94，p<0.001），尤其是在B细胞急性淋巴细胞白血病亚组中（A与G相比：OR = 0.79，95%CI = 0.74，0.83，p<0.001），但在T细胞急性淋巴细胞白血病或急性髓细胞白血病亚组中未观察到这种关联。在按种族进行的分层分析中，在欧洲人群中观察到了这种关联（A与G相比：OR = 0.80，95%CI = 0.76，0.84，p<0.001），但在亚洲人群和混合人群中未观察到。此外，敏感性分析和累积荟萃分析的结果表明我们的结果具有稳健性。而且，Begg检验和Egger检验均未表明存在明显不对称的任何证据。总之，我们的研究提供了证据，表明CEBPE rs2239633变体与欧洲儿童B细胞急性淋巴细胞白血病风险降低有关。
