Zhang Xiao-Xia, Du Yue-Feng, Zhai Ya-Jing, Gao Fan, Yang Yu-Juan, Ma Xian-Cang, Lu Jun, Zheng Jie
Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Department of Urology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Onco Targets Ther. 2015 Sep 7;8:2443-51. doi: 10.2147/OTT.S89661. eCollection 2015.
Acute lymphoblastic leukemia (ALL) has been studied intensively for decades, but the details of its etiology and underlying mechanisms have yet to be fully elucidated. It is now generally acknowledged that genetic factors contribute greatly to the development of this disease. The gene encoding CCAAT/enhancer-binding protein ε (CEBPE) is involved in the development of leukemia, and in particular the rs2239633 single nucleotide polymorphism (SNP) of CEBPE. The association between rs2239633 and risk of ALL has been well studied, but remains unclear. Therefore, a meta-analysis was performed in this study to establish a more precise estimation of that relationship. A comprehensive literature search of the PubMed electronic database was conducted, and relevant studies published up to February 20, 2015 were selected for analysis. The references of the retrieved articles were also screened. The extracted data were analyzed statistically, and pooled odds ratios with 95% confidence intervals were calculated using Review Manager (version 5.2) to estimate the association strength. Finally, eleven studies were included in the meta-analysis. The pooled analyses revealed that rs2239633 was associated with an increased risk of childhood ALL in Caucasians under any contrast models (P<0.01). However, this SNP did not affect the risk of ALL in adulthood among Caucasians, or in childhood among East Asians. In conclusion, these findings confirm that the CEBPE rs2239633 SNP could be considered a good marker of pediatric ALL risk in Caucasians, but not in East Asians; it is not a good marker of adult ALL risk in Caucasians.
几十年来，人们对急性淋巴细胞白血病（ALL）进行了深入研究，但其病因和潜在机制的细节尚未完全阐明。现在人们普遍认为，遗传因素在这种疾病的发生发展中起着很大作用。编码CCAAT/增强子结合蛋白ε（CEBPE）的基因参与白血病的发生发展，尤其是CEBPE的rs2239633单核苷酸多态性（SNP）。rs2239633与ALL风险之间的关联已得到充分研究，但仍不明确。因此，本研究进行了一项荟萃分析，以更精确地估计这种关系。我们对PubMed电子数据库进行了全面的文献检索，并选择截至2015年2月20日发表的相关研究进行分析。对检索到的文章的参考文献也进行了筛选。对提取的数据进行统计学分析，并使用Review Manager（版本5.2）计算合并比值比及其95%置信区间，以估计关联强度。最后，有11项研究纳入了荟萃分析。汇总分析显示，在任何对比模型下，rs2239633与白种人儿童ALL风险增加相关（P<0.01）。然而，该SNP对白种人成年人或东亚儿童的ALL风险没有影响。总之，这些发现证实，CEBPE rs2239633 SNP可被视为白种人儿童ALL风险的良好标志物，但不适用于东亚人；它不是白种人成人ALL风险的良好标志物。
