抗霉菌枯草菌素对红细胞及人工膜的作用。

Action of mycosubtilin on erythrocytes and artificial membranes.

作者信息

Besson F, Quentin M J, Michel G

机构信息

Laboratoire de Biochimie Microbienne (CNRS UA 1176), Université Claude Bernard, Villeurbanne, France.

出版信息

Microbios. 1989;59(240-241):137-43.

PMID:2593867

Abstract

Mycosubtilin has a strong lytic action upon erythrocytes. The haemolytic effect of the antibiotic is inhibited by free cholesterol as well as cholesterol included in liposomes of phosphatidylcholine-cholesterol. The antibiotic binding on artificial membranes was studied with radioactive bilayer vesicles of dipalmitoylphosphatidylcholine (DPPC), and DPPC-cholesterol:mycosubtilin destroyed both kinds of vesicles. The inhibition of the haemolytic effect of mycosubtilin by liposomes is a result of an interaction which diminishes the concentration of free cholesterol.

摘要

抗霉枯草菌素对红细胞有很强的溶解作用。游离胆固醇以及包含在磷脂酰胆碱 - 胆固醇脂质体中的胆固醇可抑制该抗生素的溶血作用。利用二棕榈酰磷脂酰胆碱（DPPC）以及DPPC - 胆固醇的放射性双层囊泡研究了抗生素在人工膜上的结合情况，结果表明抗霉枯草菌素可破坏这两种囊泡。脂质体对抗霉枯草菌素溶血作用的抑制是一种相互作用的结果，这种相互作用会降低游离胆固醇的浓度。