Quentin M J, Besson F, Peypoux F, Michel G
Biochim Biophys Acta. 1982 Jan 22;684(2):207-11. doi: 10.1016/0005-2736(82)90007-4.
Iturin A, bacillomycin L and bacillomycin L dimethyl ester have a strong lytic activity upon human erythrocytes while iturin C is totally inactive. The hemolytic action of the antibiotics is inhibited by free cholesterol as well as by cholesterol included in mixed liposomes of phosphatidylcholine-cholesterol and to a lesser extent by phosphatidylcholine liposomes. This inhibition is the result of an interaction between the antibiotic and added lipids which diminishes the concentration of free antibiotic available to lyse erythrocytes. The inhibitory effect of liposomes on hemolysis demonstrated the affinity of the antibiotic for artificial membrane, especially those containing cholesterol.
伊枯草菌素A、芽孢杆菌霉素L和芽孢杆菌霉素L二甲酯对人红细胞具有很强的裂解活性，而伊枯草菌素C则完全无活性。游离胆固醇以及包含在磷脂酰胆碱 - 胆固醇混合脂质体中的胆固醇可抑制抗生素的溶血作用，磷脂酰胆碱脂质体的抑制作用较小。这种抑制作用是抗生素与添加的脂质之间相互作用的结果，该相互作用降低了可用于裂解红细胞的游离抗生素的浓度。脂质体对溶血的抑制作用证明了抗生素对人工膜，尤其是含胆固醇人工膜的亲和力。
