González-Ramírez Mónica P, Miravete-Lagunes Karla, Gómez-de-León Andrés, Ponce-de-León Sergio, Tenorio-Rojo Andrea P, Martagón-Herrera Nora A, Hernández-Reyes Jesús A, García-Villasenor Arturo, Burguette Esteban, Vallejo-Villalobos María Fernanda, Ruiz-Delgado Guillermo J, Gómez-Almaguer David, Ruiz-Argüelles Guillermo J
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.
Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Rev Invest Clin. 2015 Mar-Apr;67(2):109-16.
Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT).
To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers.
By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reduced-intensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital "Dr. José Eleuterio González" of the Universidad Autónoma de Nuevo León, and who had survived more than 12 months after the allograft, who could be approached, who were in a continued complete remission (with or without graft-versus-host disease), and who were willing to respond to the questionnaire. Thirty-five patients fulfilling these requirements were included, and a sex- and age-matched group of 35 reference subjects was also studied.
Allografted patients were found to have a slightly better mental component summary than the reference subjects (53.23 vs. 48.66 points; p = 0.01), whereas the physical component summary did not show a difference (54.53 vs. 52.05 points; p = 0.59). Most of the differences between allografted individuals and reference subject controls were not significant.
Despite several sources of bias, these data suggest that allografted individuals employing the Mexican reduced-intensity conditioning regimen enjoy a health-related QOL life similar to that of reference subjects, adding another advantage of this method of conducting stem cell allografts. However, more work needs to be done to elucidate the impact of reduced-intensity conditioning on post allo-HCT QOL.
生活质量（QOL）是对诸如异基因造血细胞移植（allo-HCT）等危及生命疾病的艰苦治疗进行咨询、实施和治疗后管理时的重要考量因素。
分析在墨西哥两个学术医疗中心接受墨西哥低强度预处理方案进行异基因移植的白血病患者的生活质量。
通过使用健康调查简表36第2版来衡量一般健康概念，对在鲁伊斯诊所的普埃布拉血液学与内科中心或新莱昂自治大学“何塞·埃莱乌特里奥·冈萨雷斯博士”医院内科血液科门诊接受低强度预处理进行异基因造血干细胞移植、移植后存活超过12个月、能够被联系上、处于持续完全缓解状态（有或无移植物抗宿主病）且愿意回答问卷的白血病患者的相关生活质量进行分析。纳入了35名符合这些要求的患者，并对35名性别和年龄匹配的参照对象组成的对照组进行了研究。
发现接受移植的患者在精神健康综合评分方面略高于参照对象（53.23分对48.66分；p = 0.01），而在生理健康综合评分方面未显示出差异（54.53分对52.05分；p = 0.59）。接受移植的个体与参照对象对照组之间的大多数差异不显著。
尽管存在多种偏差来源，但这些数据表明，采用墨西哥低强度预处理方案进行移植的个体与参照对象的健康相关生活质量相似，这为这种干细胞移植方法增添了另一个优势。然而，仍需要开展更多工作以阐明低强度预处理对异基因造血干细胞移植后生活质量的影响。
