Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal,
Environ Sci Pollut Res Int. 2015 Sep;22(17):13382-92. doi: 10.1007/s11356-015-4589-1. Epub 2015 May 5.
An increasing number of studies established unequivocal relationships between exposure to pharmaceutical drugs and toxicity in wildlife. However, few studies investigated physiological alterations caused by such compounds in polychaetes. Thus, in this study, the effects of increasing concentrations of paracetamol were studied in the polychaete Diopatra neapolitana using tissue regenerative capacity as a biomarker. The obtained results revealed that individuals exposed to ecologically relevant concentrations (namely, 25 μg/L) of paracetamol exhibited significantly lower capacity to regenerate their body in comparison with control organisms. This study evidenced that paracetamol can induce significant physiological alterations in D. neapolitana resulting in an overall diminished regenerative capacity, which is of significance to a species with high ecological and economic relevance. Additionally, this study indicates the promise of D. neapolitana as a test organism in laboratory-based bioassays, but also as an adequate sentinel species to pharmaceutical drugs.
越来越多的研究确立了暴露于药物与野生动物中毒之间的明确关系。然而，很少有研究调查此类化合物在多毛类动物中引起的生理变化。因此，在这项研究中，使用组织再生能力作为生物标志物，研究了扑热息痛浓度增加对多毛类动物 Diopatra neapolitana 的影响。研究结果表明，与对照生物相比，暴露于生态相关浓度（即 25μg/L）扑热息痛的个体的身体再生能力显著降低。这项研究表明，扑热息痛会在 D. neapolitana 中引起显著的生理变化，导致整体再生能力下降，这对于具有高生态和经济重要性的物种具有重要意义。此外，这项研究表明 D. neapolitana 作为实验室生物测定中的测试生物具有潜力，并且也是一种合适的药物监测指示物种。
