Green Douglas R
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
EMBO Rep. 2015 Jun;16(6):674-5. doi: 10.15252/embr.201540470. Epub 2015 May 4.
Receptor‐interacting protein kinase‐1 (RIPK1) sits at a signaling node controlling a number of functional pathways. These include both positive and negative control of apoptosis and necroptosis (a form of regulated necrosis). In this issue of EMBO Reports, Yonekawa and colleagues describe another function for RIPK1, the inhibition of autophagy via ERK‐mediated phosphorylation of the transcription factor, TFEB [1]. Their findings are considered in the context of RIPK1 signaling, and how it is engaged.
受体相互作用蛋白激酶1（RIPK1）处于控制多个功能通路的信号节点。这些通路包括对细胞凋亡和坏死性凋亡（一种程序性坏死形式）的正向和负向调控。在本期《EMBO报告》中，米川及其同事描述了RIPK1的另一个功能，即通过细胞外调节蛋白激酶（ERK）介导的转录因子TFEB磷酸化来抑制自噬[1]。我们将结合RIPK1信号传导及其激活方式来探讨他们的研究发现。
