调控性细胞坏死：不断扩展的非细胞凋亡性细胞死亡途径网络。
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
机构信息
1] Molecular Signaling and Cell Death Unit, Inflammation Research Center, Flanders Institute for Biotechnology (VIB), Ghent University, 9052 Ghent, Belgium. [2].
1] Division of Nephrology and Hypertension, Christian-Albrechts-University, 24105 Kiel, Germany. [2].
出版信息
Nat Rev Mol Cell Biol. 2014 Feb;15(2):135-47. doi: 10.1038/nrm3737.
Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
细胞死亡研究因认识到坏死可以以高度调控和基因控制的方式发生而重新焕发生机。虽然 RIPK1（受体相互作用蛋白激酶 1）和 RIPK3-MLKL（混合谱系激酶结构域样）介导的坏死性凋亡是最被理解的受调控的坏死形式，但其他形式的该过程正在出现，包括称为 parthanatos、oxytosis、ferroptosis、NETosis、pyronecrosis 和 pyroptosis 的细胞死亡机制。阐明这些受调控的坏死途径在分子水平上是如何相互关联的，应该能够使该过程成为治疗靶点。
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