磷酸胆碱抗体在 ANCA 相关性血管炎中减少。
Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis.
机构信息
Clinical and Experimental Immunology, Maastricht University, Maastricht, The Netherlands.
Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
出版信息
Eur J Clin Invest. 2015 Jul;45(7):686-91. doi: 10.1111/eci.12457. Epub 2015 Jun 1.
BACKGROUND/AIM: ANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV.
METHODS
Pc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured.
RESULTS
Pc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only.
CONCLUSION
Atheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.
背景/目的：抗中性粒细胞胞浆抗体相关性血管炎（AAV）是一种自身免疫性小血管血管炎，目前的文献表明，它可能与动脉粥样硬化加速有关。针对氧化脂蛋白（OxLDL）和磷酸胆碱（Pc）的抗体可预防动脉粥样硬化。本研究旨在对 AAV 中的这些抗体进行特征分析。
方法
检测 39 例 AAV 患者和 44 例健康对照者（HC）血清中的 Pc 抗体和抗 OxLDL 抗体。测量颈动脉内膜中层厚度（IMT）和脉搏波速度（PWV，股动脉）。
结果
AAV 患者的 Pc-/OxLDL IgM 抗体显著降低。仅在 HC 中，IMT 和 PWV 与抗 Pc 抗体呈负相关。
结论
AAV 患者的抗 Pc/抗 OxLDL 抗体明显减少，这可能解释了血管炎患者的动脉粥样硬化加速。
Zotero 插件