Fujii H, Yamashima T, Higashi S, Hashimoto M, Yamamoto S
Department of Neurosurgery, Kanazawa University School of Medicine, Japan.
Neurochirurgia (Stuttg). 1989 Nov;32(6):165-7. doi: 10.1055/s-2008-1054029.
Intracranial pressure (ICP) was recorded in 30 dogs which underwent cisternal injection of blood, serum, red blood cells (RBC). RBC ghosts, oxyhemoglobin or bilirubin. The amount of injection was 8-10 ml of blood or an equivalent volume of blood components. Blood or RBC showed a sustained ICP of 15 to 25 mmHg, and RBC ghosts caused a slight transient rise of ICP. In contrast, oxyhemoglobin or bilirubin induced marked intracranial hypertension up to 60-80 mmHg which was associated with frequent pressure waves. Histological examination disclosed aseptic meningitis at the base of the brain and inflammatory changes in the floor of the fourth ventricle after the injection of oxyhemoglobin or bilirubin. It is suggested that the breakdown products of RBC might be causative factors of the intracranial hypertension following subarachnoid hemorrhage.
对30只狗进行了颅内压（ICP）记录，这些狗接受了小脑延髓池注射血液、血清、红细胞（RBC）、红细胞影、氧合血红蛋白或胆红素。注射量为8 - 10毫升血液或等量的血液成分。血液或红细胞导致颅内压持续在15至25 mmHg，而红细胞影引起颅内压轻微短暂升高。相比之下，氧合血红蛋白或胆红素引起高达60 - 80 mmHg的明显颅内高压，并伴有频繁的压力波。组织学检查显示，在注射氧合血红蛋白或胆红素后，脑底部出现无菌性脑膜炎，第四脑室底部出现炎症变化。提示红细胞的分解产物可能是蛛网膜下腔出血后颅内高压的致病因素。
