Duflou H, Maenhaut W, De Reuck J
Laboratory of Analytical Chemistry, Institute for Nuclear Sciences, Gent, Belgium.
Neurochem Res. 1989 Nov;14(11):1099-112. doi: 10.1007/BF00965616.
Eight elements (i.e. K, Ca, Mn, Fe, Cu, Zn, Se, and Rb) were measured in 50 different regions of 12 normal human brains by particle-induced X-ray emission (PIXE) analysis. The dry weight concentrations of K, Fe, Cu, Zn, Se, and Rb were consistently higher for gray than for white matter areas. The K, Zn and Se concentrations for the regions of mixed composition and, to some extent, also the Rb concentrations, were intermediate between the gray and white matter values, and they tended to decrease with decreasing neuron density. The mean dry weight concentrations of K, Ca, Zn, Se, and Rb in the various brain regions were highly correlated with the mean wet-to-dry weight ratios of these regions. For Mn, Fe, and Cu, however, such a correlation was not observed, and these elements exhibited elevated levels in several structures of the basal ganglia. For K, Fe, and Se the concentrations seemed to change with age. A hierarchical cluster analysis indicated that the structures clustered into two large groups, one comprising gray and mixed matter regions, the other white and mixed matter areas. Brain structures involved in the same physiological function or morphologically similar regions often conglomerated in a single subcluster.
通过粒子诱导X射线发射（PIXE）分析，对12个正常人类大脑的50个不同区域中的8种元素（即钾、钙、锰、铁、铜、锌、硒和铷）进行了测量。灰质区域中钾、铁、铜、锌、硒和铷的干重浓度始终高于白质区域。混合成分区域的钾、锌和硒浓度，以及在一定程度上铷的浓度，介于灰质和白质值之间，并且它们倾向于随着神经元密度的降低而降低。不同脑区中钾、钙、锌、硒和铷 的平均干重浓度与这些区域的平均湿重与干重比高度相关。然而，对于锰、铁和铜，未观察到这种相关性，并且这些元素在基底神经节的几个结构中表现出升高的水平。对于钾、铁和硒，其浓度似乎随年龄而变化。层次聚类分析表明，这些结构聚为两大类，一类包括灰质和混合质区域，另一类包括白质和混合质区域。参与相同生理功能或形态相似区域的脑结构通常聚集在单个子簇中。
