联合 BRAF 靶向治疗和免疫检查点阻断治疗转移性黑色素瘤的协同证据。
Evidence of synergy with combined BRAF-targeted therapy and immune checkpoint blockade for metastatic melanoma.
机构信息
Division of Surgical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Genomic Medicine; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Division of Surgical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
出版信息
Oncoimmunology. 2014 Dec 13;3(9):e954956. doi: 10.4161/21624011.2014.954956. eCollection 2014 Oct.
Significant advances in the treatment of melanoma have been made with BRAF-targeted therapy and immune checkpoint blockade, and these strategies are now being combined empirically in clinical trials. Potential synergy is demonstrated in murine models and in analysis of longitudinal biopsies from patients on trial, however important questions remain regarding toxicity, optimal timing and sequence of therapy.
在黑色素瘤的治疗方面取得了重大进展，包括 BRAF 靶向治疗和免疫检查点阻断，目前这些策略正在临床试验中进行经验性联合。在小鼠模型和临床试验中进行的纵向活检分析中显示出了潜在的协同作用，然而，关于毒性、最佳治疗时机和顺序等问题仍然存在。
Zotero 插件