Hämäläinen Suvi-Tuulia, Turunen Kaisa, Kosunen Elise, Mattila Kari J, Sumanen Markku
University of Tampere, Tampere, Finland Ikaalinen Health Center, Ikaalinen, Finland
University of Tampere, Tampere, Finland.
Am J Mens Health. 2016 Nov;10(6):NP71-NP77. doi: 10.1177/1557988315584795. Epub 2015 May 5.
Little is known about the effects of mother's intrahepatic cholestasis of pregnancy (ICP) on the health of sons born to these mothers. The purpose of the present study was to explore the health of sons born to mothers with ICP. The study design was a retrospective study of ICP mothers' sons. In the region of Tampere University Hospital in Finland, 365 sons of mothers with ICP during 1969 to 1988 and 617 sons of mothers without ICP were sent a questionnaire in 2010. The response rates were 37.8% (n = 138) and 36.6% (n = 226), respectively. Only minor differences were reported between the two groups. Self-evaluated health was similar. There were no significant differences between the groups regarding symptoms and complaints, diagnosed diseases, mental health, and use of medicines. Cough was 10.8 percentage points less common among ICP mothers' sons than among controls (p = .034). Urticaria was more common among ICP mothers' sons, the difference in percentage points being 2.2 (p = .026). In general, a mother's ICP does not affect her son's health.
关于母亲妊娠期肝内胆汁淤积症（ICP）对其儿子健康的影响，人们了解甚少。本研究的目的是探究患有ICP的母亲所生儿子的健康状况。该研究设计为对患有ICP的母亲的儿子进行回顾性研究。在芬兰坦佩雷大学医院所在地区，2010年向1969年至1988年期间患有ICP的母亲的365名儿子以及未患ICP的母亲的617名儿子发放了问卷。回复率分别为37.8%（n = 138）和36.6%（n = 226）。两组之间仅报告了细微差异。自我评估的健康状况相似。两组在症状和主诉、诊断出的疾病、心理健康以及用药方面没有显著差异。患有ICP的母亲的儿子中咳嗽的发生率比对照组低10.8个百分点（p = 0.034）。患有ICP的母亲的儿子中荨麻疹更为常见，百分点差异为2.2（p = 0.026）。总体而言，母亲的ICP不会影响其儿子的健康。
