Department of General Practice, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland; Janakkala Health Centre, Tapailanpiha 13 B, 14200 Turenki, Finland; Science Center, Tampere University Hospital, 33521 Tampere, Finland; Centre for General Practice, Pirkanmaa Hospital District, 33521 Tampere, Finland.
Department of General Practice, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.
Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:109-112. doi: 10.1016/j.ejogrb.2019.06.008. Epub 2019 Jun 15.
Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder during pregnancy. ICP has been associated with morbidity but little is known about women's long-term survival. Our aim was to determine whether ICP is associated with mothers' long-term survival.
The study population comprised 571 women with ICP in at least one pregnancy seen at Tampere University Hospital in Finland between 1969‒1988. The reference group comprised 1333 women: the previous and the following participant in the maternity ward diary. The data were obtained from Statistics Finland in March 2017 containing deaths among the study participants between 1971‒2015. The follow-up time of the cohort was 27-46 years. The Kaplan-Meier method was used.
Totally, 39 of the mothers with ICP (6.8%) and 111 of the reference group (8.3%) had died by the end of 2015 (p = 0.267). The mean survival time of ICP women was 77.4 years and of the reference group 79.2 years (p = 0.288). The mean survival time from labour in the ICP group was 45.0 years and in the reference group 44.8 years (p = 0.259).
Based on this study ICP does not seem to be associated with women's survival. There is no need to follow-up ICP mothers' health because of the nonexistent risk of premature death.
妊娠肝内胆汁淤积症（ICP）是妊娠期间最常见的肝脏疾病。ICP 与发病率有关，但对女性的长期生存情况知之甚少。我们的目的是确定 ICP 是否与母亲的长期生存有关。
研究人群包括芬兰坦佩雷大学医院 1969 年至 1988 年期间至少有一次妊娠 ICP 的 571 名妇女。对照组包括 1333 名妇女：产科病房日记中的前一名和后一名参与者。数据于 2017 年 3 月从芬兰统计局获得，包含研究参与者在 1971 年至 2015 年期间的死亡情况。队列的随访时间为 27-46 年。使用 Kaplan-Meier 法。
到 2015 年底，共有 39 名 ICP 母亲（6.8%）和 111 名对照组母亲（8.3%）死亡（p=0.267）。ICP 妇女的平均生存时间为 77.4 岁，对照组为 79.2 岁（p=0.288）。ICP 组的平均分娩后生存时间为 45.0 岁，对照组为 44.8 岁（p=0.259）。
根据这项研究，ICP 似乎与女性的生存无关。由于不存在过早死亡的风险，因此无需对 ICP 母亲的健康进行随访。
