血管紧张素原 M235T 多态性与亚洲人群肥厚型心肌病易感性的关系：荟萃分析。
Angiotensinogen M235T polymorphism and susceptibility to hypertrophic cardiomyopathy in Asian population: A meta analysis.
机构信息
Department of Cardiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Internal Medicine Teaching and Research Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320978100. doi: 10.1177/1470320320978100.
OBJECTIVE
To explore the relationship between the polymorphism of angiotensinogen gene (AGT) M235T and susceptibility to hypertrophic cardiomyopathy (HCM) in Asian population by meta-analysis.
METHODS
PubMed, Embase, Web of Science, Cochrane library, CNKI, Wan Fang, and other databases were searched to collect the literature about AGT M235T polymorphism and HCM from the inception to March 1, 2020. The Newcastle-Ottawa Scale (NOS) checklist was uesd to perform independent literature review and study quality assessment. Data was analyzed by Stata 15.0 software.
RESULTS
The results showed that, except for the recessive genetic model (TT vs MT+MM: OR = 1.27, 95%CI: 1.05-1.53), in the other four genetic models, the M235T polymorphism had no significant correlation with the risk of HCM (T vs M: OR = 1.17, 95%CI: 0.88-1.57; TT+MT vs MM: OR = 1.13, 95%CI: 0.55-2.33; TT vs MM: OR = 1.25, 95%CI: 0.60-2.59; TM vs MM: OR = 0.95, 95%CI0.5-1.82). The results of subgroup analysis showed that, except for the heterozygous genetic model, in the other four genetic models, M235T polymorphism was significantly associated with sporadic hypertrophic cardiomyopathy (SHCM), but not with familial hypertrophic cardiomyopathy (FHCM) ( > 0.05).
CONCLUSION
M235T polymorphism in Asians is associated with HCM, especially SHCM. Heterozygotes increase the risk of patients with SHCM.
目的
通过荟萃分析探讨血管紧张素原基因（AGT）M235T 多态性与亚洲人群肥厚型心肌病（HCM）易感性的关系。
方法
检索 PubMed、Embase、Web of Science、Cochrane 图书馆、CNKI、万方等数据库，收集截至 2020 年 3 月 1 日关于 AGT M235T 多态性与 HCM 的文献，采用 Newcastle-Ottawa 量表（NOS）评价文献质量，采用 Stata15.0 软件进行数据处理。
结果
结果显示，除隐性遗传模型（TT 基因型与 MT+MM 基因型相比：OR=1.27，95%CI：1.05-1.53）外，其余 4 种遗传模型中，M235T 多态性与 HCM 风险均无显著相关性（T 基因型与 M 基因型相比：OR=1.17，95%CI：0.88-1.57；TT+MT 基因型与 MM 基因型相比：OR=1.13，95%CI：0.55-2.33；TT 基因型与 MM 基因型相比：OR=1.25，95%CI：0.60-2.59；TM 基因型与 MM 基因型相比：OR=0.95，95%CI：0.5-1.82）。亚组分析结果显示，除杂合遗传模型外，其余 4 种遗传模型中，M235T 多态性与散发性肥厚型心肌病（SHCM）显著相关，与家族性肥厚型心肌病（FHCM）无关（ > 0.05）。
结论
亚洲人群中 M235T 多态性与 HCM 相关，尤其与 SHCM 相关。杂合子增加了 SHCM 患者的发病风险。
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