Abboud Bassam
Bassam Abboud, Department of General Surgery, Hotel Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
World J Gastroenterol. 2015 Apr 28;21(16):4802-8. doi: 10.3748/wjg.v21.i16.4802.
Inflammatory fibroid polyps (IFPs), or Vanek's tumor, are one of the least common benign small bowel tumors. IFP affects both sexes and all age groups, with a peak of incidence in the fifth and seventh decades. They can be found throughout the gastrointestinal tract but most commonly in the gastric antrum or ileum. The underlying cause of IFPs is still unknown. Genetic study of IFP showed mutations in platelet derived growth factor alpha in some cases. At the time of diagnosis most IFPs have a diameter of 3 to 4 cm. The lesions have always been recorded as solitary polyps. Symptoms depend on the location and the size of the lesion, including abdominal pain, vomiting, altered small bowel movements, gastrointestinal bleeding and loss of weight. IFPs arising below the Treitz ligament can present with an acute abdomen, usually due to intussusceptions. Abdominal computed tomography is currently considered the most sensitive radiological method to show the polyp or to confirm intussusceptions. Most inflammatory fibroid polyps can be removed by endoscopy. Surgery is rarely needed. Exploratory laparoscopy or laparotomy is frequently recommended as the best treatment for intussusceptions caused by IFP. The operation should be performed as early as possible in order to prevent the intussusceptions from leading to ischemia, necrosis and subsequent perforation of the invaginated bowel segment. This report aims at reviewing the diagnosis, etiology, genetics, clinical presentation, endoscopy, radiology, and best treatment of IFP.
炎症性纤维瘤性息肉(IFPs),即瓦内克瘤,是最罕见的良性小肠肿瘤之一。IFP可发生于任何性别和所有年龄组,发病高峰在50至70岁之间。它们可见于整个胃肠道,但最常见于胃窦或回肠。IFP的潜在病因尚不清楚。对IFP的基因研究显示,部分病例存在血小板衍生生长因子α的突变。在诊断时,大多数IFP的直径为3至4厘米。这些病变一直被记录为孤立性息肉。症状取决于病变的位置和大小,包括腹痛、呕吐、小肠运动改变、胃肠道出血和体重减轻。Treitz韧带以下发生的IFP可表现为急腹症,通常是由于肠套叠所致。目前,腹部计算机断层扫描被认为是显示息肉或确诊肠套叠最敏感的影像学方法。大多数炎症性纤维瘤性息肉可通过内镜切除。很少需要进行手术。对于由IFP引起的肠套叠,通常建议采用探索性腹腔镜检查或剖腹手术作为最佳治疗方法。手术应尽早进行,以防止肠套叠导致套入肠段缺血、坏死及随后的穿孔。本报告旨在综述IFP的诊断、病因、遗传学、临床表现、内镜检查、影像学及最佳治疗方法。