Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo 663-8501, Japan.
Stem Cells Int. 2015;2015:630693. doi: 10.1155/2015/630693. Epub 2015 Apr 6.
Following the discovery of pluripotent stem (PS) cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, there has been a great hope that injured tissues can be repaired by transplantation of ES/iPS-derived various specific types of cells such as neural stem cells (NSCs). Although PS cells can be induced by ectopic expression of Yamanaka's factors, it is known that several stimuli such as ischemia/hypoxia can increase the stemness of somatic cells via reprogramming. This suggests that endogenous somatic cells acquire stemness during natural regenerative processes following injury. In this study, we describe whether somatic cells are converted into pluripotent stem cells by pathological stimuli without ectopic expression of reprogramming factors based on the findings of ischemia-induced multipotent stem cells in a mouse model of cerebral infarction.
继多能干细胞（如胚胎干细胞 [ES] 和诱导多能干细胞 [iPS]）的发现之后，人们寄希望于通过移植 ES/iPS 衍生的各种特定类型的细胞（如神经干细胞 [NSC]）来修复受损组织。尽管可以通过异位表达 Yamanaka 因子来诱导多能干细胞，但已知几种刺激因素（如缺血/缺氧）可以通过重编程增加体细胞的干性。这表明内源性体细胞在受伤后的自然再生过程中获得干性。在这项研究中，我们根据脑梗死小鼠模型中缺血诱导的多能干细胞的发现，描述了在没有异位表达重编程因子的情况下，病理刺激是否会将体细胞转化为多能干细胞。
