Lin Yuankai, Li Jianrui, Zhang Zhiqiang, Xu Qiang, Zhou Zhenyu, Zhang Zhongping, Zhang Yong, Zhang Zongjun
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; School of Medical Imaging, Xuzhou Medical College, Xuzhou 221000, China.
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Biomed Res Int. 2015;2015:234245. doi: 10.1155/2015/234245. Epub 2015 Apr 5.
Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D (∗)), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated and then coregistered to generate the corresponding parameter values. We found CBF and D (∗) were higher in the high grade gliomas, whereas ADC, D, and f were lower (all P < 0.05). In differentiating the high from low grade gliomas, the maximum areas under the curves (AUC) of D (∗), CBF, and ADC were 0.857, 0.85, and 0.902, respectively. CBF was negatively correlated with f in tumor (r = -0.619, P = 0.001). ADC was positively correlated with D in both tumor and white matter (r = 0.887, P = 0.000 and r = 0.824, P = 0.000, resp.). There was no correlation between CBF and D (∗) in both tumor and white matter (P > 0.05). IVIM DWI showed more efficiency than 3D pCASL but less validity than conventional DWI in differentiating the high from low grade gliomas.
胶质瘤分级对于治疗方案至关重要；我们旨在通过与三维伪连续动脉自旋标记（3D pCASL）相比较，研究体素内不相干运动（IVIM）扩散加权成像（DWI）在胶质瘤分级中的应用。24例患者（13例高级别胶质瘤和11例低级别胶质瘤）在术前接受了IVIM DWI和3D pCASL成像；计算快速扩散系数（D(∗)）、慢速扩散系数（D）、灌注相关体积分数（f）、表观扩散系数（ADC）以及脑血流量（CBF）的图谱，然后进行配准以生成相应的参数值。我们发现高级别胶质瘤中的CBF和D(∗)较高，而ADC、D和f较低（均P < 0.05）。在区分高级别和低级别胶质瘤时，D(∗)、CBF和ADC的曲线下最大面积（AUC）分别为0.857、0.85和0.902。肿瘤内CBF与f呈负相关（r = -0.619，P = 0.001）。肿瘤和白质中ADC与D均呈正相关（分别为r = 0.887，P = 0.000和r = 0.824，P = 0.000）。肿瘤和白质中CBF与D(∗)均无相关性（P > 0.05）。在区分高级别和低级别胶质瘤方面，IVIM DWI比3D pCASL更有效，但比传统DWI有效性更低。
