从克隆的蜈蚣藻中分离得到的硫酸化多糖及其抗凝活性。
Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity.
作者信息
Chen Xiaolin, Yang Shengfeng, Wang Jinxia, Song Lin, Xing Ronge, Liu Song, Yu Huahua, Li Pengcheng
机构信息
Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao, Shandong 266071, China.
Qingdao Tumor Hospital, No. 127 Siliu Nan Road, Qingdao, Shandong 266042, China.
出版信息
Biomed Res Int. 2015;2015:612352. doi: 10.1155/2015/612352. Epub 2015 Apr 7.
Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed that GSP was mainly sulfated polysaccharides of galactose. The experiments for activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) anticoagulant assays in vitro indicated that GSP was a good potential anticoagulant. Therefore, this study supplied new thought for the cloned Grateloupia filicina exploitation of high-value products.
从在中国青岛胶州湾养殖的克隆蜈蚣藻中分离出硫酸化多糖（GSP）。GSP的产量为15.75%。总糖和硫酸盐含量分别为40.90%和19.89%。平均分子量为11.7 kDa。中性糖分析结果表明，GSP主要是半乳糖的硫酸化多糖。体外活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）和凝血酶时间（TT）抗凝试验结果表明，GSP具有良好的潜在抗凝作用。因此，本研究为克隆蜈蚣藻高价值产品的开发提供了新思路。
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