高密度脂蛋白和载脂蛋白E基因变异与年龄相关性黄斑变性的关联

Association of high-density lipoprotein and apolipoprotein E genetic variants with age-related macular degeneration.

作者信息

Cezario Sabrina Mayara, Calastri Maria Clara Jéssica, Oliveira Camila Ive Ferreira, Carmo Tayanne Silva, Pinhel Marcela Augusta de Souza, Godoy Moacir Fernandes de, Jorge Rodrigo, Cotrim Carina Costa, Souza Dorotéia Rossi Silva, Siqueira Rubens Camargo

机构信息

Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.

Medical School of Ribeirão Preto, Ribeirão Preto, SP, Brazil.

出版信息

Arq Bras Oftalmol. 2015 Mar-Apr;78(2):85-8. doi: 10.5935/0004-2749.20150023.

DOI:10.5935/0004-2749.20150023

PMID:25945528

Abstract

PURPOSE

This study aimed to evaluate the association of age-related macular degeneration (AMD) with apolipoprotein E (APOE) variants and serum lipid profiles, including levels and fractions of total serum cholesterol (TC), low-density lipoprotein cholesterol (LDLc), and high-density lipoprotein cholesterol (HDLc), and triglycerides (TG).

METHODS

Genotyping of APOE-HhaI was performed in 134 patients (study group, SG) and 164 individuals without AMD (control group, CG), aged 50-89 years. Lipid profiles were analyzed in a subgroup of 30 subjects of both groups, matched according to age and sex. The significance level was set at P<0.05.

RESULTS

APOE E3/E3 was more prevalent (SG=74.6%; CG=77.4%), with no difference between both groups (P=0.667). The same result was observed for risk genotypes (APOE E -/2: SG=7.4%; CG=10.3%, P=0.624). Serum levels of TC, LDLc, and TG revealed similar median values between SG (193.5, 116, and 155 mg/dL, respectively) and CG (207.5, 120, and 123.5 mg/dL, respectively; P >0.05). For HDLc, a higher median value was observed in SG (53.3 mg/dL) versus CG (42.5 mg/dL; P=0.016). Logistic regression analysis showed the same value, and the HDLc/TC ratio was -11.423 (P=0.014), as also confirmed by an increase in HDLc in SG. The association between lipid profiles and apolipoprotein E genotypes was similar in both groups (P>0.05).

CONCLUSION

APOE-HhaI is not associated with AMD. However, an increase in serum HDLc level appears to exert a protective effect against the disease, irrespective of the genetic variants of apoE.

摘要

目的

本研究旨在评估年龄相关性黄斑变性（AMD）与载脂蛋白E（APOE）变体以及血清脂质谱之间的关联，血清脂质谱包括总血清胆固醇（TC）、低密度脂蛋白胆固醇（LDLc）、高密度脂蛋白胆固醇（HDLc）水平及组分，以及甘油三酯（TG）。

方法

对134例年龄在50 - 89岁的患者（研究组，SG）和164例无AMD的个体（对照组，CG）进行APOE-HhaI基因分型。对两组中各30名按年龄和性别匹配的受试者亚组进行脂质谱分析。显著性水平设定为P<0.05。

结果

APOE E3/E3更为常见（SG = 74.6%；CG = 77.4%），两组之间无差异（P = 0.667）。风险基因型（APOE E -/2）的情况相同（SG = 7.4%；CG = 10.3%，P = 0.624）。SG组（分别为193.5、116和155 mg/dL）和CG组（分别为207.5、120和123.5 mg/dL；P>0.05）的血清TC、LDLc和TG水平显示出相似的中位数。对于HDLc，SG组（53.3 mg/dL）的中位数高于CG组（(42.5 mg/dL；P = 0.016）。逻辑回归分析显示相同结果，HDLc/TC比值为 -11.423（P = 0.014），SG组HDLc升高也证实了这一点。两组中脂质谱与载脂蛋白E基因型之间关联相似（P>0.05）。