Jokinen T S, Tiira K, Metsähonkala L, Seppälä E H, Hielm-Björkman A, Lohi H, Laitinen-Vapaavuori O
Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Department of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland.
J Vet Intern Med. 2015 Jul-Aug;29(4):1081-7. doi: 10.1111/jvim.12611. Epub 2015 May 6.
Lagotto Romagnolo (LR) dogs with benign juvenile epilepsy syndrome often experience spontaneous remission of seizures. The long-term outcome in these dogs currently is unknown. In humans, behavioral and psychiatric comorbidities have been reported in pediatric and adult-onset epilepsies.
HYPOTHESIS/OBJECTIVES: The objectives of this study were to investigate possible neurobehavioral comorbidities in LR with a history of benign familial juvenile epilepsy (BFJE) and to assess the occurrence of seizures after the remission of seizures in puppyhood.
A total of 25 LR with a history of BFJE and 91 control dogs of the same breed.
Owners of the LR dogs in the BFJE and control groups completed an online questionnaire about each dog's activity, impulsivity, and inattention. Principal component analysis (PCA) served to extract behavioral factors from the data. We then compared the scores of these factors between the 2 groups in a retrospective case-control study. We also interviewed all dog owners in the BFJE group by telephone to inquire specifically about possible seizures or other neurological problems after remission of seizures as a puppy.
Lagotto Romagnolo dogs with BFJE showed significantly higher scores on the factors Inattention and Excitability/Impulsivity than did the control group (P = .003; P = .021, respectively). Only 1 of the 25 BFJE LR exhibited seizures after remission of epilepsy in puppyhood.
Although the long-term seizure outcome in BFJE LR seems to be good, the dogs exhibit behavioral abnormalities resembling attention deficit hyperactivity disorder (ADHD) in humans, thus suggesting neurobehavioral comorbidities with epilepsy.
患有良性幼年癫痫综合征的拉戈托罗马尼奥洛犬（LR犬）常常会出现癫痫发作的自发缓解。目前这些犬的长期预后尚不清楚。在人类中，小儿癫痫和成人癫痫均有行为和精神共病的报道。
假设/目的：本研究的目的是调查有良性家族性幼年癫痫（BFJE）病史的LR犬可能存在的神经行为共病，并评估幼犬期癫痫发作缓解后癫痫复发的情况。
共有25只患有BFJE病史的LR犬和91只同品种对照犬。
BFJE组和对照组的LR犬主人完成了一份关于每只犬的活动、冲动性和注意力不集中情况的在线问卷。主成分分析（PCA）用于从数据中提取行为因素。然后，在一项回顾性病例对照研究中，我们比较了两组之间这些因素的得分。我们还通过电话采访了BFJE组的所有犬主人，专门询问幼犬期癫痫发作缓解后是否可能出现癫痫发作或其他神经问题。
患有BFJE的拉戈托罗马尼奥洛犬在注意力不集中和易激惹/冲动性因素上的得分显著高于对照组（分别为P = 0.003；P = 0.021）。25只患有BFJE 的LR犬中只有1只在幼犬期癫痫发作缓解后出现癫痫复发。
尽管BFJE LR犬的癫痫长期预后似乎良好，但这些犬表现出类似于人类注意力缺陷多动障碍（ADHD）的行为异常，因此提示癫痫存在神经行为共病。
