戈达香叶和嫩枝中的抗炎性萜类化合物。
Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora.
机构信息
†State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
‡Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, People's Republic of China.
出版信息
J Nat Prod. 2015 May 22;78(5):1037-44. doi: 10.1021/np5010196. Epub 2015 May 6.
Nine new terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane diterpenoids (5-10), along with six known terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 μM, respectively.
从 Dysoxylum gotadhora 的叶和小枝中分离得到了 9 种新的萜类化合物（1-3、5-10），包括 3 种环羊毛甾烷三萜（1-3）和 6 种异松烷二萜（5-10），以及 6 种已知萜类化合物（4、11-15）。化合物 1 代表一类罕见的天然 21,24-环氧环羊毛甾烷型三萜类化合物，化合物 2 和 3 则是 21,25-环氧环羊毛甾烷型三萜类化合物的首例。化合物 1、2、4、8 和 15 对 RAW 264.7 细胞中脂多糖诱导的一氧化氮生成具有显著的抑制作用，其 IC50 值分别为 25.5、41.5、27.4、14.5 和 45.2 μM。
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