State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):234-42. doi: 10.1021/np400700g. Epub 2014 Feb 18.
Fourteen new dammarane-type triterpenoids (1-14) and 11 known analogues were isolated from the stem bark of Dysoxylum binecteriferum. The absolute configurations were established by comparison with the literature or by Mo2(OAc)4-induced electronic circular dichroism data. All isolates were evaluated for their cytotoxicities against three human cancer cell lines as well as their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Compounds 4 and 8 displayed moderate cytotoxicities against HepG2 with IC50 values of 6.5 and 8.0 μM, respectively.
从双齿花椒茎皮中分离得到了 14 个新的达玛烷型三萜（1-14）和 11 个已知类似物。通过与文献比较或通过 Mo2(OAc)4 诱导的电子圆二色谱数据确定了绝对构型。所有分离物均针对三种人癌细胞系的细胞毒性以及对 RAW264.7 细胞中脂多糖诱导的一氧化氮产生的抑制作用进行了评估。化合物 4 和 8 对 HepG2 表现出中等的细胞毒性，IC50 值分别为 6.5 和 8.0 μM。
