Czarnecki W, Czarnecki A
II Department of Cardiology, Grochowski Hospital, Warsaw, Poland.
Pharmacol Res. 1989 Sep-Oct;21(5):587-94. doi: 10.1016/1043-6618(89)90200-4.
Haemodynamic effects of inosine were studied in intact dogs and subsequently in patients suffering from prolonged otherwise intractable cardiogenic shock. The nucleoside significantly improve myocardial performance in patients with an extremely low cardiac index by 63 +/- 29% as well as animals with no signs of haemodynamic deterioration, increasing cardiac output by 12.2 +/- 4.3%. These results suggest that inosine may become a promising inotropic agent. Further studies though are necessary to elucidate the mechanism of inosine action.
在完整的狗身上研究了肌苷的血流动力学效应，随后又在患有长期难治性心源性休克的患者身上进行了研究。该核苷显著改善了心脏指数极低的患者的心肌功能，改善幅度为63±29%，对于没有血流动力学恶化迹象的动物，心输出量增加了12.2±4.3%。这些结果表明，肌苷可能成为一种有前景的正性肌力药物。不过，还需要进一步研究以阐明肌苷的作用机制。
