St Johnston Daniel
The Gurdon Institute and The Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
PLoS Biol. 2015 May 6;13(5):e1002149. doi: 10.1371/journal.pbio.1002149. eCollection 2015 May.
Since its heyday in the 1980s and 90s, the field of developmental biology has gone into decline; in part because it has been eclipsed by the rise of genomics and stem cell biology, and in part because it has seemed less pertinent in an era with so much focus on translational impact. In this essay, I argue that recent progress in genome-wide analyses and stem cell research, coupled with technological advances in imaging and genome editing, have created the conditions for the renaissance of a new wave of developmental biology with greater translational relevance.
自20世纪80年代和90年代的鼎盛时期以来,发育生物学领域已走向衰落;部分原因是它被基因组学和干细胞生物学的兴起所掩盖,部分原因是在一个如此关注转化影响的时代,它似乎变得不那么相关了。在本文中,我认为全基因组分析和干细胞研究的最新进展,再加上成像和基因组编辑方面的技术进步,为具有更大转化相关性的新一轮发育生物学复兴创造了条件。