Noda Nobuo N, Fujioka Yuko
Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan,
Cell Mol Life Sci. 2015 Aug;72(16):3083-96. doi: 10.1007/s00018-015-1917-z. Epub 2015 May 7.
Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy.
自噬体形成是自噬过程中的一个标志性事件，它由自噬相关蛋白（Atg蛋白）的协同作用完成。在所有Atg蛋白中，酵母中的Atg1激酶及其在高等真核生物中的对应物ULK1激酶，在这一过程中作为最上游的因子发挥作用，并介导自噬的起始。在这篇综述中，我们总结了目前关于Atg1家族激酶在自噬起始过程中的结构、分子功能及调控的相关知识。
