From the School of Medicine and Pharmacology, University of Western Australia, Queen Elizabeth Medical Centre Unit, Perth, Australia (LCB, RLP, WHL, KZ, and JRL); the Departments of Endocrinology and Diabetes (RLP, KZ, and JRL), Renal Medicine (WHL), and Cardiology (PLT), Sir Charles Gairdner Hospital, Perth, Australia; the School of Medicine and Pharmacology, University Western Australia, Royal Perth Hospital, Perth, Australia (LCB and JMH); and the School of Exercise and Health Science, Edith Cowan University, Perth, Australia (AD).
Am J Clin Nutr. 2015 Jun;101(6):1263-8. doi: 10.3945/ajcn.114.102392. Epub 2015 May 6.
The reduction of saturated fatty acid (SFA) intake has been the basis of long-standing dietary recommendations. However, recent epidemiologic studies have reported conflicting evidence in the relation between SFA consumption and risk of atherosclerotic vascular disease (ASVD) mortality.
We investigated the association of SFA intake with serum lipid profiles and ASVD mortality in a population-based 10-y cohort study.
At baseline (1998) 1469 women living in Perth, Western Australia, with a mean ± SD age of 75.2 ± 2.7 y had SFA intake measured by using a validated food-frequency questionnaire. Outcome data were serum lipids at baseline and ASVD deaths over 10 y (13,649 person-years of follow-up), retrieved from the Western Australian Data Linkage System. Other risk factors for ASVD were assessed and adjusted for in multivariable analyses.
ASVD deaths occurred in 9.1% (134) of participants. The highest quartile of SFA intake (>31.28 g/d) had an ~16% cumulative mortality risk compared with ~5% in the lowest quartile (<17.39 g/d) (HR: 3.07; 95% CI: 1.54, 6.11; P = 0.001). Baseline SFA intake was associated with baseline serum total and LDL cholesterol in multivariable-adjusted models (β: 0.199, SE: 0.056, P < 0.001 and β: 0.190, SE: 0.051, P < 0.001, respectively). However, baseline serum total and LDL cholesterol were not associated with ASVD mortality.
High SFA intake was associated with the risk of ASVD mortality in this population of elderly women. Although there was a strong positive association between SFA intake and LDL cholesterol, LDL cholesterol was not associated with ASVD mortality in this cohort. Nevertheless, these data support dietary advice to reduce SFA intake.
减少饱和脂肪酸（SFA）的摄入一直是长期以来饮食建议的基础。然而，最近的流行病学研究报告称，SFA 摄入与动脉粥样硬化性血管疾病（ASVD）死亡率之间的关系存在相互矛盾的证据。
我们在一项基于人群的 10 年队列研究中调查了 SFA 摄入与血清脂质谱和 ASVD 死亡率之间的关系。
在基线（1998 年）时，西澳大利亚州珀斯市的 1469 名平均年龄为 75.2±2.7 岁的女性通过使用经过验证的食物频率问卷测量 SFA 摄入量。通过从西澳大利亚州数据链接系统中检索到的 10 年期间的基线血清脂质和 ASVD 死亡数据（13649 人年的随访）来评估其他 ASVD 风险因素，并在多变量分析中进行调整。
在 9.1%（134 人）的参与者中发生了 ASVD 死亡。与最低四分位数（<17.39 g/d）相比，SFA 摄入量最高四分位数（>31.28 g/d）的累积死亡率风险约为 16%（HR：3.07；95%CI：1.54，6.11；P=0.001）。在多变量调整模型中，基线 SFA 摄入量与基线血清总胆固醇和 LDL 胆固醇相关（β：0.199，SE：0.056，P<0.001 和 β：0.190，SE：0.051，P<0.001）。然而，基线血清总胆固醇和 LDL 胆固醇与 ASVD 死亡率无关。
在这群老年女性中，高 SFA 摄入量与 ASVD 死亡率风险相关。尽管 SFA 摄入量与 LDL 胆固醇之间存在强烈的正相关，但在该队列中，LDL 胆固醇与 ASVD 死亡率无关。尽管如此，这些数据支持减少 SFA 摄入的饮食建议。
