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体内神经可塑性：在间隔损伤后，记忆的阿片类敏感性逐渐发展。

Neural plasticity in vivo: opioid sensitivity of memory develops gradually after a septal lesion.

作者信息

Mondadori C, Back M

机构信息

Pharmaceutical Research Department, CIBA-GEIGY Ltd., Basle, Switzerland.

出版信息

Psychopharmacology (Berl). 1989;99(3):294-8. doi: 10.1007/BF00445546.

DOI:10.1007/BF00445546
PMID:2594896
Abstract

Neuronal plasticity can manifest itself in alterations in the sensitivity of memory to the effects of drugs. After the production of a brain lesion, the memory processing of a passive-avoidance task in mice gradually becomes sensitive to the effect of morphine, i.e., an improvement in retention performance is seen after 6 weeks, but not after 1 or 2 weeks. The results presented demonstrate that, even if they lead to no discernible changes in behaviour, plastic processes can still be detected by means of behavioural tests.

摘要

神经元可塑性可表现为记忆对药物作用的敏感性改变。在造成脑损伤后，小鼠被动回避任务的记忆处理逐渐对吗啡的作用变得敏感，即6周后可见记忆保持能力提高，但1周或2周后则不然。所呈现的结果表明，即使它们不会导致行为上可察觉的变化，仍可通过行为测试检测到可塑性过程。

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