Dar Shabir Ahmad, Kaur Rajdeep
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.
Toxicol Int. 2014 Sep-Dec;21(3):283-7. doi: 10.4103/0971-6580.155364.
Dermal exposure of cypermethrin, a type II synthetic pyrethroid insecticide, at dose rate of 0.25% for 14 consecutive days produced mild signs of toxicity in buffalo calves. It produced significant elevation in the levels of alanine aminotransferase (ALT; 39.5%), aspartate aminotransferase (AST; 32.0%), blood urea nitrogen (BUN; 57.7%), and plasma creatinine (30.0%). Cypermethrin also produced significant decrease in the hemoglobin (Hb) concentration (5.4%), packed cell volume (PCV; 3.4%), and total erythrocytic count (4.0%). Additionally, there was a significant increase in erythrocytic sedimentation rate (ESR; 3.1%). On the basis of the present study, it can be concluded that cypermethrin induces significant biochemical and hematological alterations in buffalo calves when exposed dermally.
氯氰菊酯是一种II型合成拟除虫菊酯类杀虫剂，以0.25%的剂量率连续14天经皮肤接触水牛犊牛后，出现了轻度中毒症状。它使丙氨酸转氨酶（ALT；升高39.5%）、天冬氨酸转氨酶（AST；升高32.0%）、血尿素氮（BUN；升高57.7%）和血浆肌酐（升高30.0%）的水平显著升高。氯氰菊酯还使血红蛋白（Hb）浓度（降低5.4%）、红细胞压积（PCV；降低3.4%）和红细胞总数（降低4.0%）显著降低。此外，红细胞沉降率（ESR；升高3.1%）显著增加。根据本研究可以得出结论，水牛犊牛经皮肤接触氯氰菊酯会引起显著的生化和血液学改变。
