Devenport L D, Hale R L
Department of Psychology, University of Oklahoma, Norman 73019.
Psychopharmacology (Berl). 1989;99(3):337-44. doi: 10.1007/BF00445554.
The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippocampal basis for ethanol psychopharmacology was examined in the present experiments. Chosen for behavioral analysis were relatively complex eight-arm radial maze tasks which have independently been shown to be sensitive to ethanol administration and hippocampal lesions. Measures included arm selection predictability, vigilance, and retardation of extinction. Bilateral hippocampal lesions or ethanol injection (1.5 g/kg, IP) produced similar effects. However, hippocampectomy did not disrupt ethanol's influence on any task. Comparatively, neocortical ablation, especially prefrontal, was quite effective in this respect. It blocked or reduced two of the drug's three behavioral effects examined here, without any strong influence of its own, and without altering blood alcohol concentration.
乙醇对行为的独特影响表明，中枢神经系统的某些部分可能对其特别敏感。主要候选部位之一是海马结构。该结构受损在各种行为任务和过程中模拟急性乙醇治疗。本实验研究了乙醇心理药理学以海马为基础的可能性。选择相对复杂的八臂放射状迷宫任务进行行为分析，这些任务已独立证明对乙醇给药和海马损伤敏感。测量指标包括臂选择可预测性、警觉性和消退延迟。双侧海马损伤或乙醇注射（1.5 g/kg，腹腔注射）产生相似的效果。然而，海马切除并未破坏乙醇对任何任务的影响。相比之下，新皮质切除，尤其是前额叶切除，在这方面相当有效。它阻断或降低了此处检测的药物三种行为效应中的两种，自身没有任何强烈影响，也没有改变血液酒精浓度。
