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Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent.调节性T细胞的情境性醛脱氢酶表达可能解释了环磷酰胺作为促炎剂和耐受性诱导剂的背景双重性。
Oncoimmunology. 2015 Mar 20;4(3):e974393. doi: 10.4161/2162402X.2014.974393. eCollection 2015 Mar.
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Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines.人红细胞醛脱氢酶对恶唑磷类药物全身解毒的相对贡献。
Drug Metab Dispos. 1997 Dec;25(12):1436-41.
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Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer.调节性 T 细胞发育、免疫和癌症中的醛脱氢酶。
Immunology. 2019 Jan;156(1):47-55. doi: 10.1111/imm.13016. Epub 2018 Nov 22.
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Human breast adenocarcinoma MCF-7/0 cells electroporated with cytosolic class 3 aldehyde dehydrogenases obtained from tumor cells and a normal tissue exhibit differential sensitivity to mafosfamide.用人乳腺癌MCF-7/0细胞进行电穿孔，这些细胞导入了从肿瘤细胞和正常组织中获得的胞质3类醛脱氢酶，结果显示其对马磷酰胺具有不同的敏感性。
Drug Metab Dispos. 1995 Oct;23(10):1080-4.
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In vitro selection for K562 cells with higher retrovirally mediated copy number of aldehyde dehydrogenase class-1 and higher resistance to 4-hydroperoxycyclophosphamide.对K562细胞进行体外筛选，以获得具有更高逆转录病毒介导的1类醛脱氢酶拷贝数和更高4-氢过氧环磷酰胺抗性的细胞。
Hum Gene Ther. 1998 Mar 20;9(5):611-9. doi: 10.1089/hum.1998.9.5-611.
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Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization.扩增脐血乙醛脱氢酶表达细胞生成刺激肢体再血管化的髓系祖细胞。
Stem Cells Transl Med. 2017 Jul;6(7):1607-1619. doi: 10.1002/sctm.16-0472. Epub 2017 Jun 15.
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A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4 CD25 FOXP3 Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition.GMCSF-神经抗原耐受疫苗在髓鞘特异性 TCR 转基因小鼠中诱导全身性 CD4 CD25 FOXP3 调节性 T 细胞淋巴细胞增多，这取决于低效率的 T 细胞抗原受体识别。
Front Immunol. 2019 Jan 10;9:3119. doi: 10.3389/fimmu.2018.03119. eCollection 2018.
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Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide.人类I类醛脱氢酶的过表达导致对4-氢过氧环磷酰胺的抗性增加。
Cancer Gene Ther. 1996 Jan-Feb;3(1):24-30.
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Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.人腮腺沃辛瘤和黏液表皮样癌中谷胱甘肽S-转移酶、DT-二氢嘧啶脱氢酶以及一种明显具有肿瘤特异性的胞质3类醛脱氢酶的过表达。
Arch Oral Biol. 1996 Jun;41(6):597-605. doi: 10.1016/0003-9969(96)00005-2.
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Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues.氯磺丙脲类似物对人类3类醛脱氢酶的抑制作用，以及对大量表达该酶的肿瘤细胞对氮杂环磷酰胺类药物的致敏作用。
Biochem Pharmacol. 1998 Feb 15;55(4):465-74. doi: 10.1016/s0006-2952(97)00475-9.
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Graft-versus-tumor effect of post-transplant cyclophosphamide-based allogeneic hematopoietic cell transplantation.移植后环磷酰胺为基础的异基因造血细胞移植的移植物抗肿瘤效应。
Front Immunol. 2024 Jun 6;15:1403936. doi: 10.3389/fimmu.2024.1403936. eCollection 2024.
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Intestinal factors promoting the development of RORγt cells and oral tolerance.促进 RORγt 细胞发育和口服耐受的肠道因素。
Front Immunol. 2023 Oct 23;14:1294292. doi: 10.3389/fimmu.2023.1294292. eCollection 2023.
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Efflux capacity and aldehyde dehydrogenase both contribute to CD8+ T-cell resistance to posttransplant cyclophosphamide.外排能力和醛脱氢酶均有助于 CD8+ T 细胞对移植后环磷酰胺的耐药性。
Blood Adv. 2022 Sep 13;6(17):4994-5008. doi: 10.1182/bloodadvances.2022006961.
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Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4 T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.移植后环磷酰胺独特地抑制小鼠 MHC 单倍体造血细胞移植后同种反应性 CD4 T 细胞的增殖和分化。
Front Immunol. 2022 Feb 15;13:796349. doi: 10.3389/fimmu.2022.796349. eCollection 2022.
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Haploidentical Hematopoietic Stem Cell Transplantation Followed by 'Post-Cyclophosphamide': The Future of Allogeneic Stem Cell Transplant.单倍体相合造血干细胞移植联合“环磷酰胺后处理”：异基因干细胞移植的未来
Clin Hematol Int. 2020 Apr 19;2(2):49-58. doi: 10.2991/chi.d.200405.001. eCollection 2020 Jun.
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Ovalbumin-Derived Peptides Activate Retinoic Acid Signalling Pathways and Induce Regulatory Responses Through Toll-Like Receptor Interactions.卵清白蛋白衍生肽通过 Toll 样受体相互作用激活维甲酸信号通路并诱导调节反应。
Nutrients. 2020 Mar 20;12(3):831. doi: 10.3390/nu12030831.
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Mechanisms of Graft-versus-Host Disease Prevention by Post-transplantation Cyclophosphamide: An Evolving Understanding.移植后环磷酰胺预防移植物抗宿主病的机制：不断发展的认识。
Front Immunol. 2019 Nov 29;10:2668. doi: 10.3389/fimmu.2019.02668. eCollection 2019.
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Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning.成人患者接受氟达拉滨和马法兰预处理后行haploidentical 与haplo-cord 移植的比较。
Blood Adv. 2019 Jun 25;3(12):1858-1867. doi: 10.1182/bloodadvances.2019000200.
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Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus.节拍性环磷酰胺可减弱 mTOR 介导的调节性 T 细胞扩增，但对接受依维莫司治疗的转移性肾细胞癌患者的临床结局无影响。
Cancer Immunol Immunother. 2019 May;68(5):787-798. doi: 10.1007/s00262-019-02313-z. Epub 2019 Feb 11.
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Characterization of the T-cell Repertoire after Autologous HSCT in Patients with Ankylosing Spondylitis.强直性脊柱炎患者自体造血干细胞移植后T细胞库的特征分析
Acta Naturae. 2018 Apr-Jun;10(2):48-57.
本文引用的文献
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Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice.供体CD4+ Foxp3+调节性T细胞对于移植后环磷酰胺介导的小鼠移植物抗宿主病保护作用是必需的。
Blood. 2014 Sep 25;124(13):2131-41. doi: 10.1182/blood-2013-10-525873. Epub 2014 Aug 18.
2
Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.醛脱氢酶表达促使人类调节性T细胞对移植后环磷酰胺产生抗性。
Sci Transl Med. 2013 Nov 13;5(211):211ra157. doi: 10.1126/scitranslmed.3006960.
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Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation.移植后环磷酰胺用于 HLA 单倍体相合骨髓移植中的诱导耐受。
Semin Oncol. 2012 Dec;39(6):683-93. doi: 10.1053/j.seminoncol.2012.09.005.
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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.表达FoxP3转录因子的人CD4+ T细胞的功能划分与分化动力学
Immunity. 2009 Jun 19;30(6):899-911. doi: 10.1016/j.immuni.2009.03.019. Epub 2009 May 21.
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Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells.环磷酰胺诱导非肥胖糖尿病（NOD）小鼠发生1型糖尿病与CD4+CD25+Foxp3+调节性T细胞数量减少有关。
J Immunol. 2006 Nov 15;177(10):6603-12. doi: 10.4049/jimmunol.177.10.6603.
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PROLONGATION OF HOMOGRAFT SURVIVAL IN MICE WITH SINGLE DOSES OF CYCLOPHOSPHAMIDE.单次给予环磷酰胺可延长小鼠同种异体移植的存活时间。
Nature. 1963 Oct 5;200:84. doi: 10.1038/200084a0.
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Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism.乳腺癌患者环磷酰胺剂量递增：对药代动力学和代谢的影响
J Clin Oncol. 1997 May;15(5):1885-96. doi: 10.1200/JCO.1997.15.5.1885.
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Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.环磷酰胺辅助的已建立肿瘤的过继性免疫疗法取决于肿瘤诱导的抑制性T细胞的清除。
J Exp Med. 1982 Apr 1;155(4):1063-74. doi: 10.1084/jem.155.4.1063.
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Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity.环磷酰胺通过抑制抑制性细胞活性逆转免疫耐受。
Nature. 1974 Jun 14;249(458):654-6. doi: 10.1038/249654a0.
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