即时检测中Alere N末端B型利钠肽原检测的评估
Evaluation of the Alere NT-proBNP Test for Point of Care Testing.
作者信息
Khezri Banafsheh Seyyed, Carlsson Lena, Larsson Anders
机构信息
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
出版信息
J Clin Lab Anal. 2016 Jul;30(4):290-2. doi: 10.1002/jcla.21853. Epub 2015 May 6.
BACKGROUND
The object of the study was to evaluate the Alere point of care NT-proBNP assay as a suitable alternative to the central laboratory method to provide short test turnaround times in primary care.
METHOD
Blood NT-proBNP results obtained with the Alere assay (n = 100) were compared with serum NT-proBNP results analyzed by a Cobas 8000 analyzer (Roche Diagnostics, Mannheim, Germany).
RESULTS
There was a good agreement between the two NT-proBNP methods when used as a rule-out test for heart failure (HF) and the cut-off value <300 ng/l. A total of 47 samples gave values <300 ng/L with both methods and 51 samples gave values >300 with both methods. Thus, there was an agreement for 98% of the samples.
CONCLUSIONS
The study shows that the Alere NT-proBNP assay could be used in primary care permitting rapid NT-proBNP testing to rule out HF.
背景
本研究的目的是评估Alere即时检测NT-proBNP检测法作为中心实验室方法的合适替代方法，以便在初级保健中提供较短的检测周转时间。
方法
将通过Alere检测法获得的血液NT-proBNP结果（n = 100）与通过Cobas 8000分析仪（德国曼海姆罗氏诊断公司）分析的血清NT-proBNP结果进行比较。
结果
当两种NT-proBNP方法用作心力衰竭（HF）的排除试验且临界值<300 ng/l时，两者之间具有良好的一致性。共有47个样本两种方法测得的值均<300 ng/L，51个样本两种方法测得的值均>300。因此，98%的样本结果一致。
结论
该研究表明，Alere NT-proBNP检测法可用于初级保健，允许快速进行NT-proBNP检测以排除HF。
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