采用钙等离子体浸没离子注入增强聚醚醚酮的成骨活性。
Enhanced osteogenic activity of poly ether ether ketone using calcium plasma immersion ion implantation.
机构信息
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
出版信息
Colloids Surf B Biointerfaces. 2016 Jun 1;142:192-198. doi: 10.1016/j.colsurfb.2016.02.056. Epub 2016 Feb 27.
As a promising implantable material, poly ether ether ketone (PEEK) possesses similar elastic modulus to that of cortical bones yet suffers from bio-inertness and poor osteogenic properties, which limits its application as orthopedic implants. In this work, calcium is introduced onto PEEK surface using calcium plasma immersion ion implantation (Ca-PIII). The results obtained from scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) confirm the modified layer with varying contents of calcium are formed on PEEK surfaces. Water contact angle measurements reveal the increasing hydrophobicity of both Ca-PIII treated surfaces. In vitro cell adhesion, viability assay, alkaline phosphatase activity and collagen secretion analyses disclose improved the adhesion, proliferation, and osteo-differentiation of rat bone mesenchymal stem cells (bMSCs) on Ca-PIII treated surfaces. The obtained results indicate that PEEK surface with enhanced osteogenic activity can be produced by calcium incorporation.
作为一种有前途的植入材料，聚醚醚酮（PEEK）具有与皮质骨相似的弹性模量，但存在生物惰性和较差的成骨性能，这限制了其作为骨科植入物的应用。在这项工作中，使用钙等离子体浸没离子注入（Ca-PIII）将钙引入 PEEK 表面。扫描电子显微镜（SEM）和 X 射线光电子能谱（XPS）的结果证实了在 PEEK 表面形成了具有不同钙含量的改性层。水接触角测量表明 Ca-PIII 处理表面的疏水性增加。体外细胞黏附、活力测定、碱性磷酸酶活性和胶原蛋白分泌分析表明，Ca-PIII 处理表面提高了大鼠骨髓间充质干细胞（bMSCs）的黏附、增殖和向成骨细胞分化。研究结果表明，通过掺入钙可以产生具有增强成骨活性的 PEEK 表面。
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