Esendagli-Yilmaz Guldal, Uluoglu Omer
Department of Medical Pathology, Faculty of Medicine, Gazi University, Yenimahalle, Ankara 06500, Turkey.
Department of Medical Pathology, Faculty of Medicine, Gazi University, Yenimahalle, Ankara 06500, Turkey.
Neuroimaging Clin N Am. 2015 May;25(2):159-61. doi: 10.1016/j.nic.2015.01.011.
Pyogenic spondylitis and discitis are usually seen following a recent infection or surgery. A septic embolus causes an infarcted area within the bone. Pyogenic spondylitis is characterized by edema, vascular leakage, and supportive inflammatory reaction characterized with polymorphonuclear leukocytes. In tuberculosis of the spine, active lesions are characterized by formation of epithelioid granulomas with central caseating necrosis. Mycobacterium tuberculosis can be shown by histochemical stains for acid-fast bacteria or by immunochemistry. In brucella spondylitis, microgranulomatous proliferation composed of histiocytes containing numerous bacilli without caseating necrosis is characteristic. Brucella melitensis can be shown on histochemical Gram stain.
化脓性脊柱炎和椎间盘炎通常在近期感染或手术后出现。脓毒性栓子会导致骨内出现梗死区域。化脓性脊柱炎的特征是水肿、血管渗漏以及以多形核白细胞为特征的支持性炎症反应。在脊柱结核中，活动性病变的特征是形成具有中央干酪样坏死的上皮样肉芽肿。结核分枝杆菌可通过抗酸菌组织化学染色或免疫化学方法显示。在布鲁氏菌性脊柱炎中，由含有大量杆菌且无干酪样坏死的组织细胞组成的微肉芽肿性增殖是其特征。马尔他布鲁氏菌可在组织化学革兰氏染色中显示。
