Carbonell-Estrany Xavier, Pérez-Yarza Eduardo G, García Laura Sanchez, Guzmán Cabañas Juana M, Bòria Elena Villarrubia, Atienza Belén Bernardo
Neonatology Service, Hospital Clinic, Institut d'Investigacions Biomediques August Pi Suñer (IDIBAPS), Barcelona, Spain.
Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain; Biomedical Research Centre Network for Respiratory Diseases (CIBERES), San Sebastián, Spain; Department of Pediatrics, University of the Basque Country (UPV/EHU), San Sebastián, Spain.
PLoS One. 2015 May 8;10(5):e0125422. doi: 10.1371/journal.pone.0125422. eCollection 2015.
The health status of premature infants born 321-350 weeks' gestational age (wGA) hospitalized for RSV infection in the first year of life (cases; n = 125) was compared to that of premature infants not hospitalized for RSV (controls; n = 362) through 6 years. The primary endpoints were the percentage of children with wheezing between 2-6 years and lung function at 6 years of age. Secondary endpoints included quality of life, healthcare resource use, and allergic sensitization. A significantly higher proportion of cases than controls experienced recurrent wheezing through 6 years of age (46.7% vs. 27.4%; p = 0.001). The vast majority of lung function tests appeared normal at 6 years of age in both cohorts. In children with pulmonary function in the lower limit of normality (FEV1 Z-score [-2; -1]), wheezing was increased, particularly for cases vs. controls (72.7% vs. 18.9%, p = 0.002). Multivariate analysis revealed the most important factor for wheezing was RSV hospitalization. Quality of life on the respiratory subscale of the TAPQOL was significantly lower (p = 0.001) and healthcare resource utilization was significantly higher (p<0.001) in cases than controls. This study confirms RSV disease is associated with wheezing in 32-35 wGA infants through 6 years of age.
将出生时孕龄为32 - 35周（wGA）且在出生后第一年因呼吸道合胞病毒（RSV）感染而住院的早产儿（病例组；n = 125）的健康状况，与未因RSV住院的早产儿（对照组；n = 362）进行了长达6年的比较。主要终点指标为2至6岁时喘息儿童的百分比以及6岁时的肺功能。次要终点指标包括生活质量、医疗资源利用情况和过敏致敏情况。在6岁前，经历反复喘息的病例组比例显著高于对照组（46.7%对27.4%；p = 0.001）。在两个队列中，绝大多数儿童在6岁时肺功能测试结果看起来正常。在肺功能处于正常下限（FEV1 Z分数[-2；-1]）的儿童中，喘息情况有所增加，尤其是病例组与对照组相比（72.7%对18.9%，p = 0.002）。多变量分析显示，喘息的最重要因素是因RSV住院。病例组在TAPQOL呼吸子量表上的生活质量显著更低（p = 0.001），且医疗资源利用率显著更高（p<0.001）。本研究证实，RSV疾病与32 - 35周孕龄婴儿在6岁前的喘息有关。
