单剂水痘疫苗未能保护癌症患儿免受危及生命的突破性水痘感染。
Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella.
作者信息
Kelley James, Tristram Debra, Yamada Masaki, Grose Charles
机构信息
From the *Division of Pediatric Infectious Diseases, Albany Medical College, Albany New York; and †Division of Infectious Diseases/Virology, Children's Hospital, University of Iowa, Iowa City, Iowa.
出版信息
Pediatr Infect Dis J. 2015 Sep;34(9):1027-9. doi: 10.1097/INF.0000000000000737.
Abstract
We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated.
摘要
我们报告了2例患有危及生命的突破性水痘的儿童。两人在患癌症前均接种过1剂水痘疫苗。尽管接受了静脉注射阿昔洛韦治疗，但1名儿童死于播散性水痘。由于已有类似的致命病例报道，对于接种过1剂水痘疫苗的高危免疫功能低下儿童，可能需要与从未接种过疫苗的免疫功能低下儿童采取相同的水痘预防措施。
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