Kadosawa Tsuyoshi, Watabe Ai
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
Vet J. 2015 Aug;205(2):175-9. doi: 10.1016/j.tvjl.2015.04.009. Epub 2015 Apr 13.
Surgical removal of primary tumours can help in the treatment of cancer but carries the risk of triggering the proliferation of dormant micrometastases. Many experimental and clinical studies have demonstrated that anti-angiogenic mechanisms and immune surveillance are essential to inhibit metastatic tumour cells from growing. As surgical stress often induces a reduction in anti-angiogenic factors in parallel with increases in angiogenic factors and suppression of immune surveillance during the post-operative period, new strategies for peri-operative immunostimulation and chemotherapy are required. This review summarises the factors and proposed mechanisms underlying the effects of surgery on immunosuppression and angiogenesis.
手术切除原发性肿瘤有助于癌症治疗，但存在触发潜伏微转移灶增殖的风险。许多实验和临床研究表明，抗血管生成机制和免疫监视对于抑制转移性肿瘤细胞生长至关重要。由于手术应激通常会导致抗血管生成因子减少，同时血管生成因子增加，且术后免疫监视受到抑制，因此需要围手术期免疫刺激和化疗的新策略。本综述总结了手术对免疫抑制和血管生成影响的相关因素及潜在机制。
