Rodigheri Sabrina Marin, Paiva Felipe Noleto de, Firmo Bruna Fernanda, Fuchs Taise, Mani Cynthia Bueno, Nardi Andrigo Barboza de
School of Health Sciences, Ecoville Campus, Positivo University (UP), Curitiba 81280-330, Brazil.
Department of Veterinary Clinic and Surgery, Faculty of Agricultural and Veterinary Sciences, Paulista State University (UNESP), Jaboticabal 14884-900, Brazil.
Animals (Basel). 2023 Mar 3;13(5):926. doi: 10.3390/ani13050926.
Surgical excision of solid tumors is required for local control of neoplasms. However, surgical trauma can stimulate the release of proangiogenic growth factors, suppressing cell-mediated immunity and favoring the development of micrometastases and progression of residual disease. The present study aimed to evaluate the intensity of the metabolic response to trauma induced via unilateral mastectomy in bitches with mammary neoplasia, the consequences of its joint performance with ovariohysterectomy, and their respective effects on the organic response. Two groups of animals were evaluated in seven perioperative moments, namely, unilateral mastectomy (G1) and unilateral mastectomy associated with ovariohysterectomy (G2). Thirty-two female dogs were selected, ten clinically healthy, and twenty-two diagnosed with mammary neoplasia. Surgical trauma reduced serum concentrations of albumin and interleukin-2 but increased blood levels of glucose and interleukin-6 in the postoperative of G1 and G2 patients. Moreover, serum cortisol levels increased after unilateral mastectomy associated with ovariohysterectomy. Our findings allowed us to conclude that unilateral mastectomy induces significant metabolic alterations in female dogs with mammary neoplasms and its joint performance with ovariohysterectomy increases the organic response to trauma.
为实现肿瘤的局部控制，需要对实体瘤进行手术切除。然而，手术创伤会刺激促血管生成生长因子的释放，抑制细胞介导的免疫，并有利于微转移的发展和残留疾病的进展。本研究旨在评估患有乳腺肿瘤的母犬单侧乳房切除所引起的创伤代谢反应强度、其与卵巢子宫切除术联合进行的后果，以及它们对机体反应的各自影响。在七个围手术期时间点对两组动物进行评估，即单侧乳房切除术（G1）和单侧乳房切除术联合卵巢子宫切除术（G2）。选择了32只雌性犬，其中10只临床健康，22只被诊断患有乳腺肿瘤。手术创伤降低了G1和G2组患者术后血清白蛋白和白细胞介素-2的浓度，但提高了血糖和白细胞介素-6的血液水平。此外，单侧乳房切除术联合卵巢子宫切除术后血清皮质醇水平升高。我们的研究结果使我们得出结论，单侧乳房切除术会在患有乳腺肿瘤的雌性犬中引起显著的代谢改变，并且其与卵巢子宫切除术联合进行会增加机体对创伤的反应。
