Mazeron Renaud, Maroun Pierre, Cao Kim, Mbagui Rodrigue, Slocker-Escarpa Andrea, Chargari Cyrus, Haie-Meder Christine
Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
Bull Cancer. 2015 May;102(5):470-6. doi: 10.1016/j.bulcan.2015.03.015. Epub 2015 May 5.
Radiation therapy may have deleterious effects on female fertility. It can cause ovarian dysfunction, uterine damages or disrupt the hypothalamic-pituitary axis. These effects occur at varying dose levels usually relatively low compared to the prescribed doses. Other co-factors influence the effects of radiation therapy on fertility, such as age or therapy with alkylating agents. This review aims to make an update on the current state of knowledge about the impact of radiotherapy on female fertility.
放射治疗可能对女性生育能力产生有害影响。它可导致卵巢功能障碍、子宫损伤或破坏下丘脑 - 垂体轴。这些影响在不同剂量水平下都会出现，通常与规定剂量相比相对较低。其他共同因素会影响放射治疗对生育能力的影响，如年龄或烷化剂治疗。本综述旨在更新关于放射治疗对女性生育能力影响的当前知识状态。
