Chargari C, Castadot P, Gillion N, Bauduceau O, Védrine L, Haie-Meder C, Spano J-P, Magné N
Service d'Oncologie Radiothérapie, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris, France.
Bull Cancer. 2009 Oct;96(10):1005-11. doi: 10.1684/bdc.2009.0949.
Although insufficiently documented, the impact of radiation therapy on fertility should not be neglected in female patients. Toxicity on reproductive function is dual and is characterized by both mechanistic deleterious effects on the genital tract and partial or complete loss of ovarian function. Moreover, gonadic toxicity may be increased by the concurrent use of chemotherapy or surgical procedure. In some circumstances, ovarian transposition may be justified for young patients. But no compromise may be accepted in terms of carcinologic results. At least, the effect of low-doses of irradiation has not been demonstrated for extra-pelvic radiotherapy.
尽管记录不足，但放射治疗对女性患者生育能力的影响不应被忽视。对生殖功能的毒性是双重的，其特征是对生殖道产生机械性有害影响以及卵巢功能部分或完全丧失。此外，同时使用化疗或手术可能会增加性腺毒性。在某些情况下，对于年轻患者，卵巢移位可能是合理的。但在肿瘤学结果方面不能有任何妥协。至少，低剂量照射对盆腔外放射治疗的影响尚未得到证实。
