Omdal R, Husby G, Hinderaker W
Tidsskr Nor Laegeforen. 1989 Nov 10;109(31):3214-5.
Coagulopathy leading to arterial and venous thrombosis is sometimes seen in patients with systemic lupus erythematosus (SLE). It is caused by antiphospholipid antibodies reacting with negatively charged phospholipid constituents of membranes and coagulation factors. The patients may also suffer from recurrent fetal loss and neurological manifestations, and may have intermittent thrombocytopenia and low serum concentration of complement factor C4. Patients without evidence of SLE or other immunological disorders may also exhibit this antiphospholipid antibody-associated thrombotic tendency. The patients are often young women, and it is important to be aware of this kind of coagulopathy, because it may take a most severe course in some of the persons affected.
系统性红斑狼疮（SLE）患者有时会出现导致动脉和静脉血栓形成的凝血病。它是由抗磷脂抗体与膜的带负电荷磷脂成分及凝血因子发生反应引起的。患者还可能反复出现胎儿丢失和神经学表现，并且可能有间歇性血小板减少和补体因子C4血清浓度降低。没有SLE或其他免疫性疾病证据的患者也可能表现出这种抗磷脂抗体相关的血栓形成倾向。这些患者通常是年轻女性，认识到这种凝血病很重要，因为在一些受影响的人身上它可能会发展为最严重的病程。
