Dolan Lianne B, Campbell Kristin, Gelmon Karen, Neil-Sztramko Sarah, Holmes Daniel, McKenzie Donald C
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
Allan McGavin Sports Medicine Clinic, 3055 Wesbrook Mall, Vancouver, BC, Canada.
Support Care Cancer. 2016 Jan;24(1):119-127. doi: 10.1007/s00520-015-2749-y. Epub 2015 May 9.
Exercise therapy is being explored in a variety of cancer populations to counteract treatment-related deconditioning. Higher intensity interval protocols are being prescribed to improve physical function and attenuate surrogates of comorbidity in non-cancer populations. The purpose of this study is to explore the safety of higher intensity exercise stimuli on cardiorespiratory fitness (VO2peak) in breast cancer survivors.
Postmenopausal breast cancer survivors were randomized into three groups: supervised aerobic interval training (AIT), supervised continuous moderate exercise training (CMT), and an unsupervised control group (CON). For 6 weeks, AIT exercised between 70 and 100% VO2peak, while CMT exercised between 60 and 70% VO2peak. Both groups followed a matched-work design.
Thirty-three participants completed the study (age, 57.2 (9) years; weight, 67.6 (12) kg) with no adverse advents. Between-group baseline values were non-significant. VO2peak at baseline (25.3 (5.4) mL·kg(-1)·min(-1)) was below population norms. Compared to CON, cardiorespiratory fitness improved in AIT and CMT by 12% (P < 0.001) with no significant difference between exercise groups. AIT had a greater influence on lower extremity strength (P = 0.026) and body weight (P = 0.031).
This pilot study provides evidence that similar to CMT, AIT can safely increase VO2peak in a small group of breast cancer survivors. Further exploration of the benefits of implementing higher intensity training protocols is warranted.
运动疗法正在多种癌症人群中进行探索，以对抗与治疗相关的身体机能下降。在非癌症人群中，正在采用更高强度的间歇训练方案来改善身体功能并减轻合并症的替代指标。本研究的目的是探讨更高强度运动刺激对乳腺癌幸存者心肺适能（最大摄氧量）的安全性。
绝经后乳腺癌幸存者被随机分为三组：有监督的有氧间歇训练（AIT）组、有监督的持续中等强度运动训练（CMT）组和无监督的对照组（CON）。为期6周，AIT组在最大摄氧量的70%至100%之间进行运动，而CMT组在最大摄氧量的60%至70%之间进行运动。两组均采用匹配工作量设计。
33名参与者完成了研究（年龄57.2（9）岁；体重67.6（12）千克），未出现不良事件。组间基线值无显著差异。基线时的最大摄氧量（25.3（5.4）毫升·千克⁻¹·分钟⁻¹）低于总体标准。与CON组相比，AIT组和CMT组的心肺适能提高了12%（P < 0.001），运动组之间无显著差异。AIT组对下肢力量（P = 0.026）和体重（P = 0.031）有更大影响。
这项初步研究提供了证据，表明与CMT组类似，AIT组可以安全地提高一小群乳腺癌幸存者的最大摄氧量。有必要进一步探索实施更高强度训练方案的益处。
