Karuppaiya Palaniyandi, Tsay Hsin Sheng
Department of Applied Chemistry, Chaoyang University of Technology, Taichung 41349, Taiwan.
Department of Applied Chemistry, Chaoyang University of Technology, Taichung 41349, Taiwan; Department of Agronomy, National Chung Hsing University, Taichung 40249, Taiwan.
Toxicol Lett. 2015 Jul 16;236(2):90-7. doi: 10.1016/j.toxlet.2015.05.004. Epub 2015 May 6.
Dysosma pleiantha (Hance) Woodson also called as Bajiaolian belongs to the family Berberidaceae, is widely used in Taiwan as traditional Chinese herbal medicine for more than thousands of years. It is usually recommended by various traditional Chinese medical doctors and herbal pharmacies for general remedies including postpartum recovery, treatment of weakness, neck mass, acne, hepatoma, lumbago, snakebite, tumor growth and dysmenorrhea. In the textbooks of traditional Chinese medicine, there is limited information about the toxicity of Bajiaolian. Podophyllotoxin, a lignan is the main toxic ingredient of Bajiaolian rhizome. Therefore, Bajiaolian is documented as the fifth highest cause of poisoning among the herbal medicine in Taiwan. Since the therapeutic and toxic doses are very close, Bajiaolian poisoning cases are frequently reported in Taiwan. Moreover, Dysosma poisoning cases are difficult to diagnosis because physicians are unfamiliar with this medicine's multiple clinical presentations in different stages of intoxication. Therefore, the objective of this review is to represent the collective information available in literatures regarding D. pleiantha, a cytotoxic lignan containing medicinal plant. Specifically, the literatures have been reviewed for articles pertaining to chemical constituents, properties, therapeutical benefits, toxicity, poisoning symptoms, toxic as well as therapeutic dose and medical management.
八角莲（Dysosma pleiantha (Hance) Woodson）又称八月莲，属于小檗科，在台湾作为传统中草药已被广泛使用了千余年。它常被各类中医和中药房推荐用于多种病症的治疗，包括产后恢复、体虚调理、颈部肿块、痤疮、肝癌、腰痛、蛇咬伤、肿瘤生长以及痛经等。在中医典籍中，关于八月莲毒性的记载有限。鬼臼毒素，一种木脂素，是八角莲根茎的主要毒性成分。因此，八月莲被列为台湾地区中草药中毒性排名第五的药物。由于治疗剂量和中毒剂量非常接近，台湾地区经常报告八月莲中毒病例。此外，八角莲中毒病例难以诊断，因为医生对这种药物在中毒不同阶段的多种临床表现并不熟悉。因此，本综述的目的是呈现有关八角莲（一种含细胞毒性木脂素的药用植物）的文献中的综合信息。具体而言，已对有关其化学成分、特性、治疗益处、毒性、中毒症状、中毒及治疗剂量以及医疗处理等方面的文献进行了综述。
