牵拉成年神经干细胞。

Pushing and pulling on adult neural stem cells.

机构信息

Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

出版信息

Cell Stem Cell. 2015 May 7;16(5):451-2. doi: 10.1016/j.stem.2015.04.011.

DOI:10.1016/j.stem.2015.04.011

PMID:25957896

Abstract

How plastic is adult neurogenesis? In this issue of Cell Stem Cell, Sierra et al. (2015) use epilepsy models to probe how hippocampal neural stem cells (NSCs) respond to graded pathological conditions. They uncover changes in cell fate potential upon NSC activation, but it comes at a cost.

摘要

成体神经发生的可塑性如何？在本期《细胞—干细胞》杂志上，Sierra 等人（2015）利用癫痫模型来探究海马神经干细胞（NSC）对分级病理条件的反应。他们揭示了 NSC 激活时细胞命运潜能的变化，但这是有代价的。