Zerwas Stephanie, Larsen Janne Tidselbak, Petersen Liselotte, Thornton Laura M, Mortensen Preben Bo, Bulik Cynthia M
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
National Centre for Register-Based Research, Aarhus University, Aarhus V, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark.
J Psychiatr Res. 2015 Jun;65:16-22. doi: 10.1016/j.jpsychires.2015.03.003. Epub 2015 Mar 13.
Our aim was to characterize the incidence rates and cumulative incidence of anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS), and examine associations among eating disorder diagnoses, suicide attempts, and mortality. Individuals born in Denmark between 1989 and 2006 were included (N = 966,141, 51.3% male). Eating disorders diagnoses (AN, broad AN, BN, EDNOS) were drawn from the Danish Psychiatric Central Research Register (PCRR) and Danish National Patient Register (NPR). Suicide attempts and deaths were captured in the NPR, the PCRR, and the Danish Civil Registration System (CRS). In females, AN had a peak hazard at approximately age 15 years, BN at 22 years, and EDNOS had an extended peak that spanned 18 years-22 years. Eating disorder diagnoses predicted a significantly higher hazard for death and suicide attempt compared with the referent of individuals with no eating disorders. In males, peak hazard for diagnosis was earlier than in females. The present study represents one of the largest and longest studies of eating disorder incidence and suicide attempts and death in both females and males. Eating disorders are accompanied by increased hazard of suicide attempts and death even in young adults.
我们的目标是确定神经性厌食症（AN）、神经性贪食症（BN）和未另行规定的进食障碍（EDNOS）的发病率和累积发病率，并研究进食障碍诊断、自杀未遂和死亡率之间的关联。纳入了1989年至2006年在丹麦出生的个体（N = 966,141，男性占51.3%）。进食障碍诊断（AN、广义AN、BN、EDNOS）取自丹麦精神病学中央研究登记册（PCRR）和丹麦国家患者登记册（NPR）。自杀未遂和死亡情况在NPR、PCRR和丹麦民事登记系统（CRS）中记录。在女性中，AN在约15岁时风险最高，BN在22岁时，EDNOS有一个持续的高峰，跨度为18岁至22岁。与无进食障碍的个体相比，进食障碍诊断预示着更高的死亡和自杀未遂风险。在男性中，诊断的风险高峰比女性更早。本研究是关于女性和男性进食障碍发病率、自杀未遂及死亡情况规模最大、时间最长的研究之一。即使在年轻人中，进食障碍也伴随着更高的自杀未遂和死亡风险。
