Kordalewska Marta, Markuszewski Michał J
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland.
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland.
J Pharm Biomed Anal. 2015 Sep 10;113:121-36. doi: 10.1016/j.jpba.2015.04.021. Epub 2015 Apr 25.
Cardiovascular diseases (CVDs) are the main cause of death globally. There is a need for the development of specific diagnostic methods, more effective therapeutic procedures as well as drugs, which can decrease the risk of deaths in the course of CVDs. For this reason, better understanding and explanation of molecular pathomechanisms of CVDs are essential. Metabolomics is focused on analysis of metabolites, small molecules which reflect the state of an organism in a certain point of time. Application of metabolomics approach in the investigation of molecular processes responsible for CVDs development may provide valuable information. In this article we overviewed recent reports employing application of untargeted and targeted metabolomic analyses in particular CVDs. Moreover, we focused on applications of various analytical platforms and metabolomics approaches which may contribute to the explanation of the pathomechanisms of different cardiovascular diseases.
心血管疾病（CVDs）是全球主要的死亡原因。需要开发特定的诊断方法、更有效的治疗程序以及药物，以降低心血管疾病病程中的死亡风险。因此，更好地理解和解释心血管疾病的分子发病机制至关重要。代谢组学专注于分析代谢物，即反映生物体在某一时刻状态的小分子。代谢组学方法在研究心血管疾病发生的分子过程中的应用可能会提供有价值的信息。在本文中，我们概述了最近关于在特定心血管疾病中应用非靶向和靶向代谢组学分析的报告。此外，我们关注各种分析平台和代谢组学方法的应用，这些应用可能有助于解释不同心血管疾病的发病机制。
